Ongoing Supervisions
Projects
Advancing the Regenerative and Translational Potential of Cellular Fibers (CellFi)
PartnerFundação para a Ciência e a Tecnologia
Mesenchymal Stem Cells Scaffold-free Cellular Fibers RegenerationAssociated Laboratory CICECO-Aveiro Institute of Materials (LA/P/0006/2020)
PartnerFundação para a Ciência e a Tecnologia
Human Platelet Lysates-based Scaffolds for Interfacial Multi-tissue Repair (INTERLYNK)
CoordinatorEuropean Comission
InterLynk aims to develop multi-tissue 3D patient-specific scaffolds by providing a portfolio of highly compatible and biofunctional composite inks and biomaterials, and streamlining their co-processing using an upgraded AM equipment. Unprecedented biofunctionality in the synthetic reconstruction of complex interfacial tissues is expect...Metabolite-activated 3D stem cell differentiation into bone (BetterBone)
PartnerFundação para a Ciência e a Tecnologia
Strategies involving mesenchymal stem cell (MSC) osteogenic differentiation have emerged as promising tools in regenerative medicine. These work by either promoting in situ regeneration, or through newly-fabricated tissue grafts, potentially overcoming clinical complications related to more conventional therapies. However, bioengineered ...PRInted Symbiotic Materials as a dynamic platform for Living Tissues production (PRISM-LT)
Local CoordinatorEuropean Comission
The EU-funded PRISM-LT project will use a hybrid living materials concept to create a flexible platform for living tissue manufacturing. The innovative bio-ink will contain stem cells integrated into a supporting matrix with engineered helper bacteria or yeast cells. The bioprinting process will produce a 3D patterned structure where st...Sondas neuronais fotónicas integradas para computação neuromórfica (PHEASANT)
PartnerFundação para a Ciência e a Tecnologia
3D cells colonization in marine-derived hydrogels through controlled micro-channels patterning for bone repair (PROMENADE)
PartnerFundação para a Ciência e a Tecnologia
magnetic; 3D cell colonization; hydrogelA bioactivated nano-layered hydrogel for dermal regeneration in hard-to-heal ulcers (BioNaNor)
Local CoordinatorOther International
Several strategies have been developed to restore dermal function. These include collagen membranes, decellularized dermis from donors or synthetic graft alternatives. So far, these approaches have been unreliable at best and auto-grafts and transplants (that both create their own problems with donor site morbidity, risk for disease transfer and...Bioengineered autonomous cell-biomaterials devices for generating humanised micro- tissues for regenerative medicine (ATLAS)
CoordinatorEuropean Comission
New generations of devices for tissue engineering (TE) should rationalize better the physical and biochemical cues operating in tandem during native regeneration, in particular at the scale/organizational-level of the stem cell niche. The understanding and the deconstruction of these factors (e.g. multiple cell types exchanging both paracrine an...Bioinspired tile-matching to create ultrastructured bone microtissues in a close-to-native fashion (TETRISSUE)
PartnerFundação para a Ciência e a Tecnologia
The driving force behind TETRISSUE is inspired in the fundamentals of the native bone regenerative process and supported by a strong technological character to produce highly vascularized ultrastructured bone replacements. Its innovative character is mainly related with the integration of key elements working in tandem: (1) bioinstructive microp...Biorrefinaria de microalgas Coccolithophore: uma abordagem para biomateriais sustentaveis (Coccolitho4BioMat)
PartnerFundação para a Ciência e a Tecnologia
Cápsulas esféricas multicompartimentalizadas de alto rendimento para a transplantação de co-culturas multimodais de células estaminais derivadas do tecido adiposo e ilhotas pancreáticas. (TranSphera)
PartnerFundação para a Ciência e a Tecnologia
Desenvolvimento de uma membrana periodontal multicamada composta por blocos inovativos a base de polimeros de origem marinha e enzima para regeneracao guiada de osso que possui mineralizacao enzimatica controlada. (MIMETIc)
PartnerFundação para a Ciência e a Tecnologia
Development of 4D wireless thermometry to target tumor ablation (PTDC/NAN-MAT/3901/2020)
PartnerFundação para a Ciência e a Tecnologia
Thermography Magnetic Nanoparticles Induced Hyperthermia BioprintingDispositivos Supramoleculares Auto-Regulados baseados na Complementaridade dos Pares de Base do ADN: Uma Tecnologia Biomimética e com Reconheciemnto Molecular para Isolar Células Específicas para Aplicações Biomédicas (SUPRASORT)
PartnerFundação para a Ciência e a Tecnologia
Enabling precision chemical methodologies applied to natural -based systems for the development of multifunctional biomedical devices (CHEM2NATURE)
Local CoordinatorEuropean Comission
CHEM2NATURE addresses current limitations of UMINHO in the Chemistry field regarding its scientific know-how and partnerships with world-leading institutions. UMINHO seeks to improve the multifunctionality of natural-origin polymers, often with limited bioactivity and stimuli-responsiveness, and increase the performance of cell-based therapies. ...European Network of Bioadhesion Expertise: Fundamental Knowledge to Inspire Advanced Bonding Technologies (COST Action CA15216)
Local CoordinatorEuropean Comission
Many organisms, ranging from bacteria and fungi to those much larger animals and plants use chemical and mechanical means to attach permanently or temporarily to surfaces. Some bioadhesives have advantages over synthetic counterparts in terms of their ability to function over a wide temperature range, in wet or dry environments, and to form stab...Extracellular matrix derived products from human placenta to engineer bone microtissues for in vitro disease models (AMNIOGEL)
CoordinatorEuropean Comission
Hidrogéis de Lisados de Plaquetas para Regeneração do Miocárdio (BEAT)
PartnerFundação para a Ciência e a Tecnologia
Human based bioinks to engineer physiologically relevant tissues (HumanINK)
CoordinatorEuropean Comission
Bioprinting techniques, which integrate 3D printing with tissue engineering by using living cells encapsulated in natural or synthetic biomaterials as bioinks, are paving the way toward devising many innovating solutions for key biomedical and healthcare challenges and heralds' new frontiers in medicine, pharmaceutical, and food industries.Human...Hydralazine: Testing an off-label effect in Castration-Resistant Prostate Cancer (HyTherCaP)
Local CoordinatorFundação para a Ciência e a Tecnologia
Prostate cancer (PCa) is one of the most commonly diagnosed malignancies worldwide and a leading cause of cancer-related deaths among men. In Portugal, it is the most incident cancer and the 3rd cause of death (1, 2). Although most of PCa are clinically indolent, a variable proportion of patients develop castration-resistant PCa (CRPC), an aggre...Marine Origin Biopolymers as Innovative Building Blocks from the Sea for the Development of Bioresorbable Multilayered Membranes for guided bone regeneration (BLUETEETH)
CoordinatorFundação para a Ciência e a Tecnologia
Natural origin polymers from algae and arthropods can be obtained in large scale, and a great effort has been paid to find applications for such high-added value materials. Periodontal disease is frequent in humans and constitutes, together with dental caries, the principal cause of tooth loss in adults. Currently, one of the available treatment...Metodologias eficientes para a conjugação de polissacarídeos naturais com péptidos para obtenção de membranas multifuncionais para regeneração periodontal. (COP2P)
PartnerFundação para a Ciência e a Tecnologia
Novel 3D platforms to engineer bone microtissues for in vitro disease models (Microbone)
CoordinatorEuropean Comission
Osteosarcoma is a rare but devastating bone tumour that mainly affects children, adolescents and elderly. This type of tumour is very resistant to therapy, being thus urgent to find new effective treatments. In vitro tumour models can recapitulate many aspects of the natural tumour environment, and could be used to improve the predictive value o...Produção de Plataformas Microcapsulares 3D+ para Avaliação Laboratorial em Larga Escala de Novas Terapias Combinatórias para o Cancro do Pâncreas (PANGEIA)
PartnerFundação para a Ciência e a Tecnologia
Tailored Elastin-like Recombinamers as Advanced Systems for Cell Therapies in Diabetes Mellitus:a Synthetic Biology Approach towards a Bioeffective and Immunoisolated Biosimilar Islet/Cell Niche (ELASTISLET)
Local CoordinatorEuropean Comission
ELASTISLET aims to create a breakthrough development in encapsulation technology and its use in cell and tissue therapies for the treatment of type 1 and 2 diabetes. ELASTISLET will combine leading technologies in biomaterial design, production and processing, cross-linking/grafting technology and cell therapy, to synergistically integrate them ...Publications
Free-standing multilayer films as growth factor reservoirs for future wound dressing applications
Hautmann, A; Kedilaya, D; Stojanovic, S; Radenkovic, M; Marx, CK; Najman, S; Pietzsch, M; Mano, JF; Groth, T
2022, BIOMATERIALS ADVANCES, 142.
>
Freestanding Magnetic Microtissues for Tissue Engineering Applications
Santos, LF; Patricio, SG; Silva, AS; Mano, JF
2022, ADVANCED HEALTHCARE MATERIALS, 11, 8.
>
G9a inhibition by CM-272: Developing a novel anti-tumoral strategy for castration-resistant prostate cancer using 2D and 3D in vitro models
Moreira-Silva, F; Outeiro-Pinho, G; Lobo, J; Guimaraes, R; Gaspar, VM; Mano, JF; Agirre, X; Pineda-Lucena, A; Prosper, F; Paramio, JM; Henrique, R; Correia, MP; Jeronimo, C
2022, BIOMEDICINE & PHARMACOTHERAPY, 150.
>
High-Throughput Production of Microsponges from Platelet Lysate for Tissue Engineering Applications
Ladeira, BMF; Gomes, MC; Custodio, CA; Mano, JF
2022, TISSUE ENGINEERING PART C-METHODS, 28, 7, 325-334.
>
Hipster microcarriers: exploring geometrical and topographical cues of non-spherical microcarriers in biomedical applications
Bjorge, IM; Correia, CR; Mano, JF
2022, MATERIALS HORIZONS, 9, 3, 908-933.
>
HUMAN PROTEIN BASED PLATFORMS FOR 3D CELL CULTURE - A NEW ERA FOR PERSONALIZED ENGINEERING TISSUES
Custodio, C; Santos, S; Deus, I; Martins, E; Mano, J
2022, TISSUE ENGINEERING PART A, 28, S415-S415.
>
Human Protein-Based Porous Scaffolds as Platforms for Xeno-Free 3D Cell Culture
Santos SC, Custódio CA, Mano JF
2022, ADVANCED HEALTHCARE MATERIALS, 11, 12.
>
HYBRID BIOINKS CONTAINING LIQUEFIED BIOFACTORIES
Ghasemzadeh-Hasankolaei, M; Correia, CR; Mano, JF
2022, TISSUE ENGINEERING PART A, 28, S185-S185.
>
Liquefied Microcapsules Compartmentalizing Macrophages and Umbilical Cord-Derived Cells for Bone Tissue Engineering
Nadine, S; Fernandes, I; Patricio, SG; Correia, CR; Mano, JF
2022, ADVANCED HEALTHCARE MATERIALS, 11, 20.
>
Macrophage-targeted shikonin-loaded nanogels for modulation of inflammasome activation
Cardoso, M; Gaspar, VM; Ferreira, C; Silvestre, R; Duarte, IF; Mano, JF
2022, NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE, 42.
>
Nanofertilizers—synthesis, advantages, and the current status
In Peng Zhang, Iseult Lynch, Jason C. White, Richard D. Handy (Eds.), Nano-Enabled Sustainable and Precision Agriculture
Rodrigues S.M.; Avellan A.; Salvador D.; Rodrigues S.; Miranda M.; Morais B.; Oliveira M.; Mano J.; Lowry G.V.
2023, Nano-enabled Sustainable and Precision Agriculture, 43-77, Elsevier.
ISBN:
978-032391233-4; 978-032399823-9
>
Animal Protein-based Soft Materials for Tissue Engineering Applications
In Helena S. Azevedo, João F. Mano, João Borges (Eds.), Soft Matter for Biomedical Applications
C. A. Custódio, S. C. Santos, C. F. Monteiro, I. A. Deus, M. C. Gomes, J. F. Mano
2021, Royal Society of Chemistry.
ISBN:
978-1-78801-757-2
>
Extending the Functionality of Marine-origin Polysaccharides Through Chemical Modification for Biomedical Applications
In Helena S. Azevedo, João F. Mano, João Borges (Eds.), Soft Matter for Biomedical Applications
João M. M. Rodrigues, Edgar J. Castanheira, Dora C. S. Costa, Djenisa H. A. Rocha, João Borges and João F. Mano
2021, 180-204, Royal Society of Chemistry (RSC).
ISBN:
978-1-78801-757-2
>
Cell-based soft biomaterials
Soft Matter for Biomaterial Applications
A. Sofia Silva, Lúcia F. Santos, Mariana B. Oliveira and João F. Mano
2021.
ISBN:
978-1-78801-757-2
>
Smart Instructive Polymer Substrates for Tissue Engineering
In Maria Rosa Aguilar, Julio San Román (Eds.), Smart Polymers and Their Applications
Catarina A.Custódio, Aránzazudel Campo, Rui L.Reis, João F.Mano
2019, 411-438, Woodhead Publishing .
ISBN:
978-0-08-102416-4
>