Mariana Coutinho Sardo

Assistant Researcher

Short CV

2016 - 2018: post-doctoral fellow at CICECO - Aveiro Institute of Materials under the supervision of Doctor Luis Mafra and Professor João Rocha;

2010 - 2016: post-doctoral fellow at CICECO - Aveiro Institute of Materials and Laboratorium für Physikalische Chemie, ETH Zürich supervised by Doctor Luis Mafra, Professor João Rocha and Professor Beat H. Meier; 

2009: PhD in Physical Chemistry: " Weak intermolecular interactions in advanced functional materials: spectroscopic and computational studies” (supervision of Prof. Paulo Ribeiro-Claro), Chemistry Department, University of Aveiro. During this period, 5 months were spent in the University of Malaga, Spain, working in the group of Professor Juan Carlos Otero, developing SERS studies on pharmaceutical compounds;

2005: Degree in Physics and Chemistry (for teaching), Univ. Aveiro (17/20) 

SCIENTIFIC INTERESTS 

- Combining high-resolution solid-state NMR methods, X-ray diffraction and computational approaches to study crystal packing interactions in small molecules (namely pharmaceuticals) and materials - NMR crystallography; 

- Study drug-drug and drug-host interactions of molecular scaffolds as drug delivery systems. 

- NMR characterization of modified nanoporous solid sorbents with potential for gas capture (by using 13C-labelled CO2 in a gas mixture); 

- NMR characterization of porous materials relevant in heterogeneous catalysis (study of Lewis and Brønsted acidity);

OTHER INTERESTS 

- Responsible for preparing and delivering solid-state NMR Hands-on courses (II Jornadas Nacionais de Caracterização de Materiais - 2017 and IV Ibero-American NMR Meeting - 2012). - Co-President of the Young Chemists Group (GQJ) of the Portuguese Chemical Society (SPQ) between 2010-2012 - Member of the organizing committee of several scientific events: Chemistry Olympics competitions, the Portuguese Physics students meeting (2004), International conference on solubility phenomena (2004), Young Portuguese Chemists meeting (2010), European Young Chemists Network (EYCN) delegates assembly (2012) and EYCN contribution to the 4EuCheMS (2012), IV Ibero-American NMR Meeting (2012).

Scientific Interests

- NMR characterization of modified nanoporous solid sorbents with potential for gas capture (by using 13C-labelled CO2 in a gas mixture);

- NMR characterization of porous materials relevant in heterogeneous catalysis (study of Lewis and Brønsted acidity);

- Combining high-resolution solid-state NMR methods, X-ray diffraction and computational approaches to study crystal packing interactions in small molecules (namely pharmaceuticals) and materials

- NMR crystallography;

- Study drug-drug and drug-host interactions of molecular scaffolds as drug delivery systems.

Present Research Group

Dr. Luis Miguel Monteiro Mafra; Professor João Rocha; Dr. Ildefonso Marin; Dr. Marina Ilkaeva, Dr. Ricardo Vieira, Dra. Paula Soares Santos; Carlos Bornes; João Pereira

Main present collaborators

Professor Beat H. Meier (ETH - Zurich); Prof. José M. Ferreira (UA); Dr. José R.B. Gomes (UA); Prof. Isabel Neves (U. Minho); Dr. Paula Ferreira (UA); Prof. Teresa Duarte (IST); Prof. Moisés Pinto (IST); Prof. Norberto Masciocchi (U. Insubria)

Selected Publications

1. "Comparison of different silica microporous structures as drug delivery systems for in vitro models of solid tumors", Natália Vilaça, Ana F. Machado, Filipa Morais-Santos, Ricardo Amorim, A. Patrícia Neto, Enora Logodin, Manuel F. R. Pereira, Mariana Sardo, João Rocha, Pier Parpot, António M. Fonseca, Fátima Baltazar and Isabel C. Neves, RSC Adv.2017, 7, 13104-13111.

2. "PAIN with and without PAR: Variants for third-spin assisted heteronuclear polarization transfer", Vipin Agarwal*, Mariana Sardo*, Ingo Scholz, Anja Böckmann, Matthias Ernst and Beat H. Meier, J. Biomol. NMR 2013, 56(4), 365-377. (*authors equally contributed for this work)

 3. "Combining multinuclear high-resolution solid-state MAS NMR and computational methods for resonance assignment of glutathione tripeptide", Mariana Sardo, Renée Siegel, Sérgio M. Santos, João Rocha, José R. B. Gomes, Luis Mafra, J. Phys. Chem. A 2012, 116 (25), 6711–6719.

4. "3D–2D–0D Stepwise Deconstruction of a Water Framework Templated by a Nanoporous Organic–Inorganic Hybrid Host", João Rocha, Fa-Nian Shi, Filipe A. Almeida Paz, Luis Mafra, Mariana Sardo, Luis Cunha-Silva, James Chisholm, Paulo Ribeiro-Claro and Tito Trindade, Chem. Eur. J. 2010, 16, 7741-7749.

Ongoing Supervisions

Projects

Publications

Enhancing Adamantylamine Solubility through Salt Formation: Novel Products Studied by X-ray Diffraction and Solid-State NMR

Martins, ICB; Sardo, M; Alig, E; Fink, L; Schmidt, MU; Mafra, L; Duarte, MT
2019, CRYSTAL GROWTH & DESIGN, 19, 3, 1860-1873.
ISBN: 1528-7505

Hydrogen bonding networks in gabapentin protic pharmaceutical salts: NMR and in silico studies

Martins, ICB; Sardo, M; Cendak, T; Gomes, JRB; Rocha, J; Duarte, MT; Mafra, L
2019, MAGNETIC RESONANCE IN CHEMISTRY, 57, 5, 243-255.
ISBN: 1097-458X

H-1-P-31 HETCOR NMR elucidates the nature of acid sites in zeolite HZSM-5 probed with trimethylphosphine oxide

Bornes, C; Sardo, M; Lin, Z; Amelse, J; Fernandes, A; Ribeiro, MF; Geraldes, C; Rocha, J; Mafra, L
2019, CHEMICAL COMMUNICATIONS, 55, 84, 12635-12638.
ISBN: 1364-548X

Revisiting the crystal structure of dickite: X-ray diffraction, solid-state NMR, and DFT calculations study

Rocha, J; Paz, FAA; Sardo, M; Mafra, L
2018, AMERICAN MINERALOGIST, 103, 5, 812-818.

Detecting Proton Transfer in CO2 Species Chemisorbed on Amine-Modified Mesoporous Silicas by Using (CNMR)-C-13 Chemical Shift Anisotropy and Smart Control of Amine Surface Density

Cendak, T; Sequeira, L; Sardo, M; Valente, A; Pinto, ML; Mafra, L
2018, CHEMISTRY-A EUROPEAN JOURNAL, 24, 40, 10136-10145.

Microwave-assisted N,N-dialkylation of amine-functionalized periodic mesoporous phenylene-silica: An easy and fast way to design materials

Lourenco, MAO; Ferreira, MJG; Sardo, M; Mafra, L; Gomes, JRB; Ferreira, P
2017, MICROPOROUS AND MESOPOROUS MATERIALS, 249, 10-15.
ISBN: 1873-3093

Comparison of different silica microporous structures as drug delivery systems for in vitro models of solid tumors

Vilaca, N; Machado, AF; Morais-Santos, F; Amorim, R; Neto, AP; Logodin, E; Pereira, MFR; Sardo, M; Rocha, J; Parpot, P; Fonseca, AM; Baltazar, F; Neves, IC
2017, RSC ADVANCES, 7, 22, 13104-13111.

Packing Interactions and Physicochemical Properties of Novel Multicomponent Crystal Forms of the Anti-Inflammatory Azelaic Acid Studied by X-ray and Solid-State NMR

Martins, ICB; Sardo, M; Santos, SM; Femandes, A; Antunes, A; Andre, V; Mafra, L; Duarte, MT
2016, CRYSTAL GROWTH & DESIGN, 16, 1, 154-166.

Interaction of CO2 and CH4 with Functionalized Periodic Mesoporous Phenylene-Silica: Periodic DFT Calculations and Gas Adsorption Measurements

Lourenco, MAO; Siquet, C; Sardo, M; Mafra, L; Pires, J; Jorge, M; Pinto, ML; Ferreira, P; Gomes, JRB
2016, JOURNAL OF PHYSICAL CHEMISTRY C, 120, 7, 3863-3875.

Diazole-based powdered cocrystal featuring a helical hydrogen-bonded network: Structure determination from PXRD, solid-state NMR and computer modeling

Sardo, M; Santos, SM; Babaryk, AA; Lopez, C; Alkorta, I; Elguero, J; Claramunt, RM; Mafra, L
2015, SOLID STATE NUCLEAR MAGNETIC RESONANCE, 65, 49-63.

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