Susana Isabel Fonseca de Almeida Santos Braga

Researcher

Contact

Department

  • Chemistry

Short CV

Graduated in Pharmaceutical Sciences from University of Porto in 1998 and a PhD in chemistry from University of Aveiro in 2003, susana has studied supramolecular host-guest systems with cyclodextrins and organic and metallo-organic species with pharmacologic interest.
Over the past five years, susana has developed ruthenium, copper and europium coordination complexes for applications in chemotherapy, disinfection and organic electronics.

Scientific Interests

I.  Cyclodextrins as nano-sized molecular capsules for
    i. biomimetic Ru(II) antitumorals
    ii. antimicrobial agents
    iii. organometalic functional complexes

II. cyclodextrins as vehycles and stabilisers for drug formulation
    i. with thymus spp oil
    ii. with occimum basilicum oil

III.  Cyclodextrins as electrical insulators for light-emmiting guests
    i. lanthanide complexes
    ii. Ru(II)-functionalized natural dyes

Main present collaborators

Coimbra - FCTUC
Maria Paula Marques
http://www1.ci.uc.pt/qfm/paula_marques.html

Lisboa - ITQB
Maria de Fátima Silva Lopes
www.itqb.unl.pt/Research/Associated_Lab/
Antibiotic_Stress_and_Virulence_of_Enterococci/

Covilhã - UBI
Ana Palmeira Oliveira
Luiza Granadeiro

Aveiro - DECV
Rui Correia 
Helena Fernandes

Aveiro - CICECO
Filipe Almeida Paz
Teresa Margarida Santos
Isabel Gonçalves 
Martyn Pillinger


Present projects

FCT 
POCI/SAU/BEB/66869/2006
PDTC/QUI/69302/2006

Selected Publications

1.      A potentiometric biosensor for D-amygdaline based on a consolidated biocomposite membrane

Arben Merkoçi, Susana Braga, Esteve Fàbregas, Salvador Alegret, Anal. Chim. Acta 391 (1999) 65-72.

2.      Encapsulation of half sandwich complexes of molybdenium with b-cyclodextrin

Susana S. Braga, Isabel S. Gonçalves, André D. Lopes, Martyn Pillinger, João Rocha, Carlos C. Romão, José J.C. Teixeira-Dias, J. Chem. Soc. Dalton Trans. (2000) 2963-2968.

3.      Experimental and theoretical study of the interaction of molybdenocene dichloride (Cp2MoCl2) with b-cyclodextrin

Susana S. Braga, Isabel S. Gonçalves, Martyn Pillinger, Paulo Ribeiro-Claro, José J.C. Teixeira-Dias, J. Organom. Chem. (2001) 11-16.

4.      Encapsulation of cyano(cyclopentadienyl) complexes of iron with b-cyclodextrin

Susana S. Braga, Isabel S. Gonçalves, Paulo Ribeiro-Claro, André D. Lopes, Martyn Pillinger, José J.C. Teixeira-Dias, João Rocha, Carlos C. Romão, Supramol. Chem. 14 (2002) 359-366.

5.      Structure of the b-Cyclodextrin×p-Hydroxybenzaldehyde Inclusion Complex in Aqueous Solution and in the Crystalline State

Susana S. Braga, Thammarat Aree, Kayo Imamura, Pierre Vertut, Isabel Boal-Palheiros, Wolfram Saenger, José J.C. Teixeira-Dias, J. Incl. Phenom. Macro. Chem. 43 (2002) 115-125.

6.      Synthesis, characterization and luminescence of b-cyclodextrin  inclusion compounds containing europium (III) and gadolinium (III) tris(b-diketonates)

Susana S. Braga, Rute A.S. Ferreira, Isabel S. Gonçalves, Martyn Pillinger, João Rocha, José J.C. Teixeira-Dias, Luís D. Carlos, J. Phys. Chem. B 106 (2002) 11430-11437.

7.      Study of the inclusion compound formed between a luminescent europium (III) b-diketonate complex and g-cyclodextrin

Susana S. Braga, Rute A. S. Ferreira, Isabel S. Gonçalves, Paulo Ribeiro-Claro, Martyn Pillinger, João Rocha, José J.C. Teixeira-Dias, Luís D. Carlos, J. Incl. Phenom. Macro. Chem. 44 (2002) 261-265.

8.      Solid State Inclusion Compound of S-Ibuprofen in b-Cyclodextrin: Structure and Characterization

Susana S. Braga, Isabel S. Gonçalves, Eberdardt Herdtweck, José J.C. Teixeira-Dias, New J. Chem. 27 (2003) 597-601.

9.      Encapsulation of sodium nimesulide and precursors in b-cyclodextrin

Susana S. Braga, Paulo Ribeiro-Claro, Martyn Pillinger, Isabel S. Gonçalves, Florbela Pereira, Ana C. Fernandes, Carlos C. Romão, Pedro B. Correia, José J.C. Teixeira-Dias, Org. Biomol. Chem. 1 (2003) 873-878. 

10.    Interactions of Omeprazole and Precursors with beta-Cyclodextrin Host Molecules

Susana S. Braga, Paulo Ribeiro-Claro, Martyn Pillinger, Isabel S. Gonçalves, Ana C. Fernandes, Florbela Pereira, Carlos C. Romão, Pedro B. Correia, José J.C. Teixeira-Dias, J. Incl. Phenom. Macro. Chem. 47 (2003) 47-52.

11.    Synthesis of ferrocenyldiimine metal carbonyl complexes and an investigation of the Mo adduct encapsulated in cyclodextrin

Željko Petrovski, Susana S. Braga, Sandra S. Rodrigues, Cláudia C. L. Pereira, Isabel S. Gonçalves, Martyn Pillinger, Cristina Freire, Carlos C. Romão, New  J. Chem. 29 (2005) 347–354 

12.    Synthesis and characterization of the inclusion compound of a ferrocenyldiimine dioxomolybdenum complex with heptakis-2,3,6-tri-O-methyl-b-cyclodextrin

Željko Petrovski, Susana S. Braga, Ana M. Santos, Sandra S. Rodrigues, Isabel S. Gonçalves, Martyn Pillinger, Fritz E. Kühn, Carlos C. Romão, Inorg. Chim. Acta 358 (2005) 981-988.

13.    Inclusion of molybdenocene dichloride (Cp2MoCl2) in 2-hydroxypropyl- and trimethyl-b-cyclodextrin: structural and biological properties

Susana S. Braga, Maria P.M. Marques, Joana B. Sousa, Martyn Pillinger, José J.C. Teixeira-Dias, Isabel S. Gonçalves, J. Organomet. Chem. 690 (2005) 2905-2912

14.    Inclusion complex formation of diferrocenyldimethylsilane with b-cyclodextrin

José A. Fernandes, Sérgio Lima, Susana S. Braga, Paulo Ribeiro-Claro, José E. Rodriguez-Borges, Cátia Teixeira, Martyn Pillinger, José J.C. Teixeira-Dias, Isabel S. Gonçalves, J. Organomet. Chem. 690 (2005) 4801-4808.

15.    Inclusion complexation of dimeric and trimeric oligo(ferrocenyl-dimethylsilanes) with g-cyclodextrin

        José A. Fernandes, Sérgio Lima, Susana S. Braga, Martyn Pillinger, Paulo Ribeiro-Claro, José E. Rodriguez-Borges, André D. Lopes, José J. C. Teixeira-Dias, Isabel S. Gonçalves, Organometallics 24 (2005) 5673-5677.

16.    Experimental and theoretical study of the encapsulation of a linear oligo(ferrocenyl-silane) trimer with b-cyclodextrin

José A. Fernandes, Sérgio Lima, Susana S. Braga, Martyn Pillinger, José E. Rodríguez-Borges, Paulo Ribeiro-Claro, José J. C. Teixeira-Dias, Isabel S. Gonçalves, Eur. J. Inorg. Chem. 23 (2005) 4729-4734.

17.    b-cyclodextrin inclusion of europium(III) tris(beta-diketonate)-bipyridine                 

        José A. Fernandes, Susana S. Braga, Martyn Pillinger, Rute A. S. Ferreira, Luís D. Carlos, Alan Hazell, Josua Jepsen, Paulo Ribeiro-Claro, Isabel S. Gonçalves, Polyhedron 25 (2006) 1471-1476.

18.    Modification of the luminescence properties of a europium(III) tris(b-diketonate) complex by inclusion in g-cyclodextrin and 2,3,6-trimethyl-g-cyclodextrin

José A. Fernandes, Susana S. Braga, Rute A. Sá Ferreira, Martyn Pillinger, Luís D. Carlos, Paulo Ribeiro-Claro, Isabel S. Gonçalves, J. Inc. Phenom Macro. Chem. 55 (2006) 329-333.

19.   Structural Studies of b-Cyclodextrin and Permethylated b-Cyclodextrin Inclusion Compounds of Cyclopentadienyl Metal Carbonyl Complexes

Susana S. Braga, Filipe A.A. Paz, Martyn Pillinger, João D. Seixas, Carlos C. Romão, Isabel S. Gonçalves, Eur. J. Inorg. Chem. (2006) 1662-1669. 

20.   Structure of Cyclopentadienyl Molybdenum Carbonyl Complexes bearing acetonitrile and bis-imine ligands and their Encapsulation in Cyclodextrins

Claudia C.L. Pereira, Susana S. Braga, Filipe A. Almeida Paz, Martyn Pillinger, Jacek Klinowski, Isabel S. Gonçalves, Eur. J. Inorg. Chem (2006) 4278-4288.

21.   b-Cyclodextrin and permethylated b-cyclodextrin inclusion compounds of a cyclopentadienyl molybdenum tricarbonyl complex and their use as cyclooctene epoxidation catalyst precursors

Susana S. Braga, Sandra Gago, João D. Seixas, Anabela A. Valente, Martyn Pillinger, Teresa M. Santos, Isabel S. Gonçalves, Carlos C. Romão, Inorg. Chim. Acta 359 (2006) 4757-4764.

22.   (2,2’-Bipyridine)tetracarbonylmolybdenum(0)

Susana S. Braga, Ana C. Coelho, Isabel S. Gonçalves and Filipe A. Almeida Paz, Acta Crystall. E: Struct. Reports Online E63 (2007) m780-m782. 

23.   A Combined Theoretical-Experimental Study of the Inclusion of Niobocene Dichloride in Native and Permethylated b-Cyclodextrins

Claudia C. L. Pereira, Mariela Nolasco, Susana S. Braga, Filipe A. Almeida Paz, Paulo Ribeiro-Claro, Martyn Pillinger, Isabel S. Gonçalves, Organometallics 26 (2007) 4220-4228.

24.   Cyclodextrin Encapsulation of Biomimetic Organometallic Cancer Drug Candidates

         Susana S. Braga, Filipe A. Almeida Paz, Vijaya Mokal, M. Pillinger, Maria Paula M. Marques, Carlos C. Romão, Isabel S. Gonçalves, Drugs Futur. 32, suppl. A (2007) 101.

25.   Influence of Cyclodextrins on Catalytic Olefin Epoxidation with Metal–      Carbonyl Compounds. Crystal Structure of the TRIMEB Complex      with CpFe(CO)2Cl

       Salete S. Balula, Ana C. Coelho, Susana S. Braga, Alan Hazell, Anabela A. Valente, Martyn Pillinger, João D. Seixas, Carlos C. Romão, Isabel S. Gonçalves, Organometallics 26 (2007) 6857-6863.

26.   Luminescence properties of the TRIMEB inclusion compound of a europium tris-β-diketonate

Susana S. Braga, Ana C. Coelho, Isabel S. Gonçalves, Gerson Santos, Fernando J. Fonseca, A.M. Andrade, Marco Peres, Wilson Simões, Teresa Monteiro, Luiz Pereira, J. Non-Cryst. Solids 354 (2008) 2736-2739.

27.   Organic Light Emitting Diodes with Europium(III) Emissive Layers based on beta-Diketonate Complexes: the Influence of the Central Ligand

Gerson Santos, Fernando J. Fonseca, A.M. Andrade, V. Deichmann, Lenny Ackcelrud, Susana S. Braga, Ana C. Coelho, Isabel S. Gonçalves, Marco Peres, Wilson Simões, Teresa Monteiro, Luiz  Pereira, J. Non-Cryst. Solids 354 (2008) 2897-2900.

28.   Synthesis, characterization and antitumor activity of 1,2-disubstituted ferrocenes and cyclodextrin inclusion complexes

Željko Petrovski, Marta R.P. Norton de Matos, Susana S. Braga, Cláudia C.L. Pereira, Márcia L. Matos, Isabel S. Gonçalves, Martyn Pillinger, Paula M. Alves, Carlos C. Romão, J. Organomet Chem 693 (2008) 675–684.

29.   Structural Studies on Supramolecular Adducts of Cyclodextrins with the Complex [Ru([9]aneS3)(bpy)Cl]Cl

Joana Marques, Lúcia Anjo, Maria Paula M. Marques, Teresa M. Santos, Filipe A. Almeida Paz, Susana S. Braga, J. Organomet. Chem. 693 (2008) 3021-3028.

30.   Complex Formation Between Heptakis(2,6-di-O-methyl)-ß-cyclodextrin and Cyclopentadienyl Molybdenum(II) Dicarbonyl complexes: Structural Studies and Cytotoxicity Evaluations

Cláudia C.L. Pereira, Cátia V. Diogo, Ana Burgeiro, Paulo J. Oliveira, Maria Paula M. Marques, Susana S. Braga, Filipe A. Almeida Paz, Martyn Pillinger, Isabel S. Gonçalves, Organometallics 27 (2008) 4948-4956.

31.   Cyclodextrins improve the Antimicrobial Activity of the chloride salt of Ruthenium(II) Chloro-phenanthroline-trithiacyclononane

Joana Marques, Teresa M. Braga, Filipe A. Almeida Paz, Teresa M. Santos, Maria de Fátima Silva Lopes, Susana S. Braga, Biometals 22 (2009) 541.

32.   Triclosan

 

 

Ana I. Ramos, Susana S. Braga, Filipe A. Almeida Paz, Acta Cryst  C65 (2009) o404.

Projects

Publications

Chloramphenicol center dot cyclodextrin inclusion compounds: co-dissolution and mechanochemical preparations and antibacterial action

Ramos, AI; Braga, TM; Silva, P; Fernandes, JA; Ribeiro-Claro, P; Lopes, MDS; Paz, FAA; Braga, SS
2013, CRYSTENGCOMM, 15, 15, 2822-2834.

Analysis of the microcrystalline inclusion compounds of triclosan with beta-cyclodextrin and its tris-O-methylated derivative

Ramos, AI; Braga, TM; Fernandes, JA; Silva, P; Ribeiro-Claro, PJ; Paz, FAA; Lopes, MFS; Braga, SS
2013, JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 80, 34-43.

Ru(II)-Based Antimicrobials: Looking Beyond Organic Drugs

Ramos, AI; Braga, TM; Braga, SS
2012, MINI-REVIEWS IN MEDICINAL CHEMISTRY, 12, 3, 227-235.

Isolation, crystal structure, and cytotoxicity on osteosarcoma of a ruthenium(III) complex with coordinated acetonitrile

Marques, J; Fernandes, JA; Paz, FAA; Marques, MPM; Braga, SS
2012, JOURNAL OF COORDINATION CHEMISTRY, 65, 14, 2489-2499.

Structural Studies and Cytotoxicity of Trimethyl(ferrocenylmethyl)ammonium Iodide Encapsulated in beta-Cyclodextrin

Bruno, SM; Fernandes, JA; Marques, J; Neto, SC; Ribeiro-Claro, PJ; Pillinger, M; Paz, FAA; Marques, MPM; Braga, SS; Goncalves, IS
2011, EUROPEAN JOURNAL OF INORGANIC CHEMISTRY, 32, 4955-4963.

Modern Alchemy with Metal Complexes Inside Cyclodextrins, The Molecular Cauldrons

Braga, SS
2010, CURRENT ORGANIC CHEMISTRY, 14, 13, 1356-1361.

Cyclodextrins improve the antimicrobial activity of the chloride salt of Ruthenium(II) chloro-phenanthroline-trithiacyclononane

Marques, J; Braga, TM; Paz, FAA; Santos, TM; Lopes, MDS; Braga, SS
2009, BIOMETALS, 22, 3, 541-556.

A glycine ruthenium trithiacyclononane complex and its molecular encapsulation using cyclodextrins

Marques, J; Santos, TM; Marques, MP; Braga, SS
2009, DALTON TRANSACTIONS, 44, 9812-9819.

Synthesis and catalytic properties of manganese(II) and oxovanadium(IV) complexes anchored to mesoporous MCM-41

Fernandes, TA; Nunes, CD; Vaz, PD; Calhorda, MJ; Brandao, P; Rocha, J; Goncalves, IS; Valente, AA; Ferreira, LP; Godinho, M; Ferreira, P
2008, MICROPOROUS AND MESOPOROUS MATERIALS, 112, 1-3, 14-25.

Luminescence properties of the TRIMEB inclusion compound of a europium tris-beta-diketonate

Braga, SS; Coelho, AC; Goncalves, IS; Santos, G; Fonseca, FJ; Andrade, AM; Peres, M; Simoes, W; Monteiro, T; Pereira, L
2008, JOURNAL OF NON-CRYSTALLINE SOLIDS, 354, 19-25, 2736-2739.

Shaping Cytotoxicity of Organometallics and Complex Antitumorals via Molecular Encapsulation

In H. F. Chin, Hauppauge (Eds.), Organometallic Compounds: Preparation, Structure and Properties
Paz F A A, Braga SS
2010, 465-481, New York, Nova Science Publishers.
ISBN: 978-1-60741-917-4

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