Bárbara Joana Martins Leite Ferreira

Junior Researcher

Contact

Department

  • Chemistry
  • 15.3.31

Research

Links

Main research interests

-Production of nanostructured platforms for drug delivery applications (inorganic nanoparticles, biopolymeric nanosystems, hybrid materials).

-in vitro release studies.

-Synthesis and characterization of new metal-based compounds (metallodrugs) and evaluation of their anti-tumoral properties.

-DNA and albumin binding capacity.

-Preparation and characterization of polymer, ceramic and composite materials for biomedical applications.

-Cytotoxicity/biocompatibility in vitro studies.

 

Master Thesis

 

2021/2022 (ongoing) – “Development of new hybrid materials capable of incorporating molecules with pharmacological activity". Sofia Pereira Viegas. Master course in Biotechnology. Supervisor team: Bárbara Leite Ferreira/José Carlos Almeida. 

2020/2021 – “Metallodrugs with antibacterial activity and their incorporation into nanocellulose membranes for wound healing applications”. Adriana Catarina da Costa Gomes. Master course in Biotechnology (Advanced Biomolecular Methods). Supervisor team: Bárbara Leite Ferreira/Carmen Freire Barros.

2019/2020 – “Design of nutraceutical-mesoporous silica nanoconjugates”. Diogo Pires Marinheiro. Master course in Biotechnology (Food). Supervisor team: Bárbara Leite Ferreira/Ana Luísa Daniel-da-Silva.

2018/2019 – “Development of new anticancer metallodrugs”, Luís Pedro Monteiro. Master course in Molecular Biomedicine, Departament of Medical Sciences. Supervisor team: Bárbara Leite Ferreira/Teresa M. Santos.

 
 
 
   
   

 

 

Final course Projects

4 ongoing (3rd year students of Biochemistry, Biotechnology and Biomedical Engineering) 

15 concluded (Biotechnology, Biochemistry and Biomedical Engineering)

International and National Conferences/Meetings - communications

[1] Luís Pedro Monteiro, Bárbara J. M. Leite Ferreira, Teresa M. Santos "New anticancer metallodrugs". XXV Encontro Luso-Galego de Química. Sociedade Portuguesa de Química (SPQ). Santiago de Compostela, Espanha. Novembro 2019 – Comunicação Oral.

[2] Luís P. Monteiro, Adriana Gomes, T. M. Santos, B. J. M. Leite Ferreira, "Novel anticancer metallodrugs", 4th Meeting of Medicinal Biotechnology, Escola Superior de Saúde, Politécnico do Porto. Porto, Portugal. Maio 2019 – Poster.

[3] Luís Pedro Monteiro, Bárbara J. M. Leite Ferreira, Teresa M. Santos, "New anticancer metallodrugs". Jornadas do CICECO 2019. Aveiro, Portugal - Poster.

[4] D. Gaspar, P. Pereira, C. Silva, F. Martel, B. J. M. Leite Ferreira, T. M. Santos, and A. L. Daniel-da-Silva, “In vitro cytotoxicity evaluation of nanostructured functionalized platforms for the sustained delivery of cisplatin”, 13th YES (Young European Scientist) Meeting 2018, Porto, Portugal. Setembro 2018 – Comunicação Oral.

[5] T. M. Santos, B. J. M. Leite Ferreira, R. Mendes, F. A. Paz, A. L. Daniel-da-Silva, “Zinc(II), Copper(II), Nickel(II) and Cobalt(II/III) mixed ligand complexes as multi-purpose metallodrugs”, 7th EuCheMS Chemistry Congress, Liverpool, Reino Unido. Agosto 2018 – Poster.

[6] T. M. Santos, B. J. M. Leite Ferreira, R. Mendes, F. A. Paz, A. L. Daniel-da-Silva, “Zinc(II), Copper(II), Nickel(II) and Cobalt(II/III) mixed ligand complexes as multi-purpose metallodrugs”, 12th Inorganic Bioinorganic Chemistry Conference (IBCC), Porto, Portugal. Julho 2018 – Poster.

[7] T. M. Santos, A. L. Daniel-da-Silva, B. J. M. Leite Ferreira, “Zinc complexes with non–steroidal anti–inflammatory drugs: synthesis, characterization and crystal structure of new complexes”, 4th EuCheS Inorganic Chemistry Conference (EICC-4), Copenhagen, Dinamarca. Julho 2017 – Poster.

[8] B. J. M. Leite Ferreira, T. M. Santos, A. L. Daniel-da-Silva, “Nanostructured magnetic platforms for the sustained delivery of anticancer drugs”, 18º Encontro da Sociedade Portuguesa de Materiais, SPM e VIII Simpósio Internacional de Materiais (Materiais 2017), Aveiro, Portugal. Abril 2017 – Poster.

[9] B. J. M. Leite Ferreira, A. L. Daniel-da-Silva, T. M. Santos, “Zinc complexes with non–steroidal anti–inflammatory drugs: Synthesis, Characterization and Crystal Structures”, International Conference on Coordination Chemistry (ICCC42), Brest, França. Julho 2016 – Poster.

[10] Teresa M. Santos, Paula Brandão, Bárbara Ferreira, Darleila Costa, João Calixto, Vítor Félix, “Copper(II) complexes with the DNA-bases adenine, cytosine and guanine: synthesis, characterization and crystal structures”, 5th International Conference EuCheMS, Istanbul, Turquia. Setembro 2014 – Poster.

[11] Teresa M. Santos, Bárbara Ferreira, “Coordination Chemistry: a bridge over troubled waters in a wonderful world (or not so …)”, 5th International Conference EuCheMS, Istanbul, Turquia . Setembro 2014 – Poster.

[12] Teresa M. Santos, Bárbara Ferreira, “Coordination Chemistry: a bridge over troubled waters in a wonderful world (or not so …) in a Wonderful World (or even better”, 11th International Conference on Hands-on Science (HSCI2014), Aveiro, Portugal. Julho 2014 – Poster.

[13] Teresa M. Santos, Paula Brandão, Bárbara Ferreira, Darleila Costa, João Calixto, Vítor Félix, “New Copper(II) Complexes with the DNA-bases cytosine and guanine: Synthesis, Characterization and Crystal Structures“, 10th Inorganic Chemistry Conference (SPQ), Costa da Caparica, Portugal. Abril 2014 – Poster.

[14] Teresa Santos, Bárbara Ferreira, Paula Brandão, Vítor Félix, “Cu(I/II) Complexes with DNA bases and polypiridylic ligands”, 3rd Portuguese Meeting on Medicinal Chemistry and 1st Portuguese-Spanish-Brazilian Meeting on Medicinal Chemistry, Aveiro, Portugal. Novembro 2012 – Poster.

[15] Teresa Santos, Bárbara Ferreira, Paula Brandão, Vítor Félix. “New Copper(I/II) Complexes with DNA bases and polypiridylic ligands”, 8th International Copper Meeting: Copper in biology, Sardenha, Itália. Outubro 2012 – Comunicação oral.

[16] Bárbara Leite Ferreira, Paula Brandão, Teresa M. Santos, Vitor Félix, “New copper(I/II) complexes coordinated with DNA bases adenine and guanine”, International Conference on Coordination Chemistry (ICCC40), Valência, Espanha. Setembro 2012 – Poster.

[17] Bárbara Ferreira,Bruno Valente,Margarida Meireles, Marli Santo, Paula Brandão, Teresa Santos, Vítor Félix, “New copper(I/II) complexes: synthesis, crystal structure and cytotoxic properties”,Internacional Symposia in Metal Complexes (ISMEC), Lisboa, Portugal. Junho 2012 – Poster.

[18] Paula Brandão,Bárbara Ferreira,Teresa M. Santos, Vítor M. Félix,“A new polycentred heptacopper(II)/adenine complex: synthesis and characterization of [Cu7(µ2-O)6(µ3-O)6(adenine)6](NO3)y.xH2O”, Internacional Symposia in Metal Complexes (ISMEC), Lisboa, Portugal. Junho 2012 – Poster.

[19] P. P. Lopes, P. S. Gomes, B. J. M. Leite Ferreira, R. N. Correia, M. H. R. Fernandes, M. H. V. Fernandes, “Bioactivity and osteoblastic behaviour of PMMA-based composites filled with silicate and borate glass”, International Bone-Tissue-Engineering Congress (BONE TEC 2009), Hannover, Alemanha. Outubro 2009 – Poster.

[20] B. J. M. Leite Ferreira, N. B. Barroca, A. Daniel-da-Silva and R. N. Correia, “Preparation and evaluation of the mechanical properties of new PMMA-co-EHA matrices for biomedical applications”, 14º Encontro da Sociedade Portuguesa de Materiais, SPM e V Simpósio Internacional de Materiais (Materiais 2009), Lisboa, Portugal. Abril 2009 – Poster.

[21] P. P. Lopes, B. Leite Ferreira, R. N. Correia, M. H. R. Fernandes and M. H. V. Fernandes, “Bioactivity and biocompatibility of a PMMA-based cement filled with a silicate and a borate glass”, 14º Encontro da Sociedade Portuguesa de Materiais, SPM e V Simpósio Internacional de Materiais (Materiais 2009), Lisboa, Portugal. Abril 2009 – Poster.

[22] P. P. Lopes, B. J. M. Leite Ferreira, R. N. Correia M. H. R. Fernandes and M. H. V. Fernandes, “Si and Ti-containing glasses as bone cement fillers: a bioactivity and biocompatibility study”, Tissue Engineering and Regenerative Medicine International Society Annual Meeting (TERMIS-EU 2008), Porto, Portugal. Junho 2008 – Poster.

[23] T. Almeida, B. J. M. Leite Ferreira, J. Loureiro, T. Lopes, R. N. Correia, C. Santos, “In vitro toxicity of novel bone cement PMMA-co-EHA”, Tissue Engineering and Regenerative Medicine International Society Annual Meeting (TERMIS-EU 2008), Porto, Portugal. Junho 2008 – Poster.

[24] P. P. Lopes, B. J. M. Leite Ferreira, R. N. Correia and M. H. V. Fernandes, “In Vitro bioactivity of PMMA-co-EHA composites filled with SiO2-Free Glass”, International Conference on Microscopy and Microanalysis (INCOMAM 07), XLII Congresso da Sociedade Portuguesa de Microscopia, Coimbra, Portugal. Dezembro 2007 – Comunicação Oral.

[25] B. J. M. Leite Ferreira, M. C. F. Magalhães and R. N. Correia, “In vitro formation of apatites and other biologically related calcium phosphates: influence of temperature and pH in the nature of the mineral phases”, 13º Encontro da Sociedade Portuguesa de Materiais, SPM e IV Simpósio Internacional de Materiais (Materais 2007), Porto, Portugal. Abril 2007 – Comunicação Oral.

[26] B. J. M. Leite Ferreira and R. N. Correia, “Preparation and in vitro characterization of chitosan/hydroxyapatite scaffolds for bone tissue engineering”, 13º Encontro da Sociedade Portuguesa de Materiais, SPM e IV Simpósio Internacional de Materiais (Materiais 2007), Porto, Portugal. Abril 2007 – Poster.

[27] M. P. Corbellini, B. J. M. Leite Ferreira, N. A. F. Almeida, M. C. Fredel, R. N. Correia and M. H. V. Fernandes, “PMMA-co-EHA glass filled composites: assessment of in vitro bioactivity”, 13º Encontro da Sociedade Portuguesa de Materiais, SPM e IV Simpósio Internacional de Materiais (Materiais 2007), Porto, Portugal. Abril 2007 – Poster.

[28] M. P. Corbellini, B. J. M. Leite Ferreira, N. A. F. Almeida, M. C. Fredel, R. N. Correia and M. H. V. Fernandes, “New PMMA-co-EHA composites for biomedical applications: development and preliminary evaluation of the mechanical properties”, V Encontro da Sociedade Brasileira de Processamento de Materiais (SBPMat), Florianópolis, Brasil. Outubro 2006 – Poster.

[29] P. P. Lopes, B. J. M. Leite Ferreira, N. A. F. Almeida, M. C. Fredel, R. N. Correia and M. H. V. Fernandes, “Preparation and study of in vitro bioactivity of PMMA-based composites filled with Ca3(PO4)2-Si-Mg glass”, V Encontro da Sociedade Brasileira de Processamento de Materiais (SBPMat) Florianópolis, Brasil. Outubro 2006 – Poster.

[30] P. P. Lopes, B. J. M. Leite Ferreira, N. A. F. Almeida, T. E. Silva, M. C. Fredel, M. H. V. Fernandes and R. N. Correia, “In vitro bioactivity of PMMA-based composite in simulated plasma with albumin”, IV Congresso Latino Americano de Orgãos Artificiais e Biomateriais (COLAOB) Minas Gerais, Brasil. Agosto 2006 – Poster.

[31] B. J. M. Leite Ferreira, M. G. G. M. Duarte, M. H. Gil, M. H. V. Fernandes, R. N. Correia, J. Róman and M. Vallet-Regí, “Mineralization of glass/PMMA-co-EHA composites: role of albumin”, VI Advanced Course in Cell-Materials Interactions at molecular level, Porto, Portugal. Junho 2005 – Poster com breve apresentação oral.

[32] P. P. Lopes, B. J. M. Leite Ferreira, N. A. F. Almeida, M. C. Fredel, M. H. V. Fernandes and R. N. Correia, “In vitro bioactivity in PMMA-based composites filled with Ca3 (PO4)2-Si-Mg glass”, VI Advanced Course in Cell-Materials Interactions at molecular level, Porto, Portugal. Junho 2005 – Poster com breve apresentação oral.

[33] B. J. M. Leite Ferreira, M. G. G. M. Duarte, M. H. Gil, R. N. Correia, J. Róman and M. Vallet-Regí, “Composite materials for bone tissue applications”, 12º Encontro da Sociedade Portuguesa de Materiais (SPM) e III Simpósio Internacional de Materiais (Materiais 2005), Aveiro, Portugal. Março 2005 – Poster.

[34] B. J. M. Leite Ferreira, M. G. G. M. Duarte, M. H. Gil, R. N. Correia, J. Róman and M. Vallet-Regí, “In vitro bioactivity in ceramic/PMMA-co-EHA composites”, II Congresso Ibérico de Biomateriais (Bioévora), Évora, Portugal. Setembro 2004 – Comunicação Oral.

[35] B. J. M. Leite Ferreira, M. G. G. M. Duarte, M. H. Gil, R. N. Correia, J. Róman and M. Vallet-Regí, “In vitro bioactivity in glass-ceramic/PMMA-co-EHA composites”, 16º Simpósio Internacional de Cerâmicos em Medicina, (Bioceramics 16), Porto, Portugal. Novembro 2003 – Comunicação Oral.

[36] B. J. M. Leite Ferreira, M. C. F. Magalhães and R. N. Correia, “Influência dos iões sódio, cloreto e carbonato na síntese da hidroxiapatite e seus precursores”, V Conferência de Química Inorgânica da Sociedade Portuguesa de Química (SPQ), Monte Real, Portugal. Abril 2001 – Poster.

 

Ongoing Supervisions

Adriana Gomes

PhD Student

Ariana Santos

PhD Student

Diogo Marinheiro

PhD Student

Publications

Resveratrol-Loaded Polydimethylsiloxane–Silica Hybrid Materials: Synthesis, Characheiroterization, and Antitumoral Activity

Sofia Viegas; Diogo Marinheiro; Veronica Bastos; Ana L. Daniel-da-Silva; Ricardo Vieira; Helena Oliveira; José Carlos Almeida; Bárbara J.M.L. Ferreira
2024, POLYMERS, 16, 7.

Silica-Based Nanomaterials for Diabetes Mellitus Treatment

Marinheiro, D; Martel, F; Ferreira, BJML; Daniel-da-Silva, AL
2023, BIOENGINEERING-BASEL, 10, 1.

Morin Hydrate Encapsulation and Release from Mesoporous Silica Nanoparticles for Melanoma Therapy

Cunha, C; Marinheiro, D; Ferreira, BJML; Oliveira, H; Daniel-da-Silva, AL
2023, MOLECULES, 28, 12.

NSAID-Based Coordination Compounds for Biomedical Applications: Recent Advances and Developments

Santos, ACF; Monteiro, LPG; Gomes, ACC; Martel, F; Santos, TM; Ferreira, BJML
2022, INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 23, 5.

Encapsulation and Enhanced Release of Resveratrol from Mesoporous Silica Nanoparticles for Melanoma Therapy

Marinheiro, D; Ferreira, BJML; Oskoei, P; Oliveira, H; Daniel-da-Silva, AL
2021, MATERIALS, 14, 6.
ISBN: 1996-1944

Nanostructured functionalized magnetic platforms for the sustained delivery of cisplatin: Synthesis, characterization and in vitro cytotoxicity evaluation

BJM Leite Ferreira, F Martel, C Silva, TM Santos, AL Daniel-da-Silva
2020, Journal of Inorganic Biochemistry, 213, 111258.

Synthesis, structural characterization, cytotoxic properties and DNA binding of a dinuclear copper(II) complex

Ferreira, BJML; Brandao, P; Meireles, M; Martel, F; Correia-Branco, A; Fernandes, DM; Santos, TM; Felix, V
2016, JOURNAL OF INORGANIC BIOCHEMISTRY, 161, 9-17.

Heptacopper(II) and dicopper(II)-adenine complexes: synthesis, structural characterization, and magnetic properties

Ferreira, BJML; Brandao, P; Dos Santos, AM; Gai, Z; Cruz, C; Reis, MS; Santos, TM; Felix, V
2015, JOURNAL OF COORDINATION CHEMISTRY, 68, 16, 2770-2787.

Properties of Novel PMMA- co- EHA Bone Cements Filled with Hydroxyapatite

Ferreira, BJML; Barroca, NB; Lopes, PP; Daniel-da-Silva, AL; Helena, VFM; Correia, RN
2014, POLYMER COMPOSITES, 35, 4, 759-767.

Influence of albumin on mineralization of PMMA-based/glass composites

Ferreira, BJML; Duarte, MGGM; Gil, MH; Fernandes, MHV; Correia, RN
2012, JOURNAL OF APPLIED BIOMATERIALS & FUNCTIONAL MATERIALS, 10, 2, 92-98.

PMMA-based bone cements with Fillers: Properties and Apllications

In Maryann C. Whythers (Eds.), Advances in Materials Science Research
B. J. M. Leite Ferreira, T. M. Santos and P. P. Lopes
2019, 1-58, New York, Nova Science Publishers.
ISBN: 978-1-53615-039-1

Application of Chitosan Based Materials for Drug Delivery

In Guilherme Luiz Dotto, Sergio Paulo Campana-Filho and Luiz Antonio de Almeida Pinto (Eds.), Frontiers in Biomaterials: Chitosan Based Materials and its Applications
Poliana P Lopes, Nathalie B Barroca, Ana Luísa Daniel-da-Silva, Bárbara J Leite Ferreira
2017, 181-248, Bentham Science Publishers.
ISBN: 978-1-68108-486-2

PMMA-co-EHA cements for osteoprostheses

Bárbara Joana Martins Leite Ferreira
2011, supervised by Rui Nunes Correia.

Formação e transformação in vitro da hidroxiapatite e seus precursores

Barbara Joana Martins Leite Ferreira
2002, supervised by Maria Clara Ferreira Magalhães.

Copper, cobalt, nickel, and zinc metallodrugs with antibacterial activity

Gomes, Adriana; Pereira, Carla; Mendes, Ricardo; Paz, Filipe; Almeida, Adelaide; Santos, T. M.; Freire, Carmen; Leite Ferreira, B. J. M
2022.

Metallodrugs with antibacterial activity and their incorporation into nanocellulose membranes for wound healing applications

Gomes, Adriana; Pereira, Carla; Mendes, Ricardo; Paz, Filipe; Almeida, Adelaide; Santos, T. M.; Freire, Carmen; Leite Ferreira, B. J. M.
2022.

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