Projects
FISHING - Fishing falcipain hit inhibitors from Malaria Boxes: in silico target deconvolution model development and validation (EXPL/QEQ-COM/0927/2013)
CoordinatorFundação para a Ciência e a Tecnologia
Malaria Virtual screening pharmacophore, docking and MD simulations Falcipains inhibitionHEDICIN - HEterocycle-DIpeptide-CINnamic acid conjugates as novel antimalarials (PTDC/QUI-QUI/116864/2010)
Local CoordinatorFundação para a Ciência e a Tecnologia
malaria blood-schizontocidals falcipain inhibition hemozoin biomineralizationPublications
Toward the discovery of inhibitors of babesipain-1, a Babesia bigemina cysteine protease: in vitro evaluation, homology modeling and molecular docking studies
Perez, B; Antunes, S; Goncalves, LM; Domingos, A; Gomes, JRB; Gomes, P; Teixeira, C
2013, JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN, 27, 9, 823-835.
>
Recycling antimalarial leads for cancer: Antiproliferative properties of N-cinnamoyl chloroquine analogues
Perez, BC; Fernandes, I; Mateus, N; Teixeira, C; Gomes, P
2013, BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 23, 24, 6769-6772.
>
Cinnamic Acid/Chloroquinoline Conjugates as Potent Agents against Chloroquine-Resistant Plasmodium falciparum
Perez, B; Teixeira, C; Gut, J; Rosenthal, PJ; Gomes, JRB; Gomes, P
2012, CHEMMEDCHEM, 7, 9, 1537-1540.
>
Novel cinnamic acid/4-aminoquinoline conjugates bearing non-proteinogenic amino acids: Towards the development of potential dual action antimalarials
Perez, BC; Teixeira, C; Figueiras, M; Gut, J; Rosenthal, PJ; Gomes, JRB; Gomes, P
2012, EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 54, 887-899.
>
PRIMACINS, N-cinnamoyl-primaquine conjugates, with improved liver-stage antimalarial activity
Perez, B; Teixeira, C; Albuquerque, IS; Gut, J; Rosenthal, PJ; Prudencio, M; Gomes, P
2012, MEDCHEMCOMM, 3, 9, 1170-1172.
>
Molecular docking and 3D-quantitative structure activity relationship analyses of peptidyl vinyl sulfones: Plasmodium Falciparum cysteine proteases inhibitors
Teixeira, C; Gomes, JRB; Couesnon, T; Gomes, P
2011, JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN, 25, 8, 763-775.
>
Viral surface glycoproteins, gp120 and gp41, as potential drug targets against HIV-1: Brief overview one quarter of a century past the approval of zidovudine, the first anti-retroviral drug
Teixeira, C; Gomes, JRB; Gomes, P; Maurel, F
2011, EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 46, 4, 979-992.
>
Falcipains, Plasmodium falciparum Cysteine Proteases as Key Drug Targets Against Malaria
Teixeira, C; Gomes, JRB; Gomes, P
2011, CURRENT MEDICINAL CHEMISTRY, 18, 10, 1555-1572.
>
Docking and 3D-QSAR studies of BMS-806 analogs as HIV-1 gp120 entry inhibitors
Teixeira, C; Serradji, N; Maurel, F; Barbault, F
2009, EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 44, 9, 3524-3532.
>
Design, Synthesis, and Biological Evaluation of N-Carboxyphenylpyrrole Derivatives as Potent HIV Fusion Inhibitors Targeting gp41.
Liu, K; Lu, H; Hou, L; Qi, Z; Teixeira, C; Barbault, F; Fan, BT; Liu, SW; Jiang, SB; Xie, L
2008, JOURNAL OF MEDICINAL CHEMISTRY, 51, 24, 7843-7854.
>