Solvatochromism as a new tool to distinguish structurally similar compounds

authors	Madeira, PP; Loureiro, JA; Freire, MG; Coutinho, JAP
nationality	International
journal	JOURNAL OF MOLECULAR LIQUIDS
author keywords	Solvatochromic method; Structurally similar compounds; Biosimilars; Quality control; Biomedical diagnosis
keywords	ELECTRONIC-SPECTRA; SOLVENT PROPERTIES; GLYCOSYLATION; PROTEINS; SCALE; WATER; BETA
abstract	It is here reported a new concept based on solvatochromism to distinguish structurally similar compounds in aqueous solutions by the analysis of the stabilization of electronic excited states. The sensitivity of this approach to differentiate similar organic compounds, such as structural isomers or compound differing in the number of methylene groups, or proteins with conformational changes induced by being or not bound to cofactors, differing in two amino acids substitutions, or differing in their glycosylation profile, is demonstrated. The sensitivity of the proposed approach, based on the solvatochromic method, opens the path to its use as an auxiliary analytical tool in biomedical diagnosis/prognosis or in quality control of biologic-based drugs. (C) 2018 Elsevier B.V. All rights reserved.
publisher	ELSEVIER SCIENCE BV
issn	0167-7322
isbn	1873-3166
year published	2019
volume	274
beginning page	740
ending page	745
digital object identifier (doi)	10.1016/j.molliq.2018.11.050
web of science category	Chemistry, Physical; Physics, Atomic, Molecular & Chemical
subject category	Chemistry; Physics
unique article identifier	WOS:000457660000082