Engineering Strategies for Allogeneic Solid Tissue Acceptance
authors Sousa, AR; Mano, JF; Oliveira, MB
nationality International
journal TRENDS IN MOLECULAR MEDICINE
keywords BONE-MARROW-TRANSPLANTATION; REGULATORY T-CELLS; MIXED HEMATOPOIETIC CHIMERISM; RENAL-ALLOGRAFT TOLERANCE; DONOR-SPECIFIC TOLERANCE; KIDNEY-TRANSPLANTATION; MONOCLONAL-ANTIBODY; NONHUMAN-PRIMATES; IMMUNE TOLERANCE; SURVIVAL
abstract Advances in allogeneic transplantation of solid organs and tissues depend on our understanding of mechanisms that mediate the prevention of graft rejection. For the past decades, clinical practice has established guidelines to prevent allograft rejection, which mostly rely on the intake of nontargeted immunosuppressants as the gold standard. However, such lifelong regimens have been reported to trigger severe morbidities and commonly fail in preventing late allograft loss. In this review, the biology of allogeneic rejection and self-tolerance is analyzed, as well as the mechanisms of cellular-based therapeutics driving suppression and/or tolerance. Bioinspired engineering strategies that take advantage of cells, biomaterials, or combinations thereof to prevent allograft rejection are addressed, as well as biological mechanisms that drive their efficacy.
publisher ELSEVIER SCI LTD
issn 1471-4914
isbn 1471-499X
year published 2021
volume 27
issue 6
beginning page 572
ending page 587
digital object identifier (doi) 10.1016/j.molmed.2021.03.005
web of science category 16
subject category Biochemistry & Molecular Biology; Cell Biology; Medicine, Research & Experimental
unique article identifier WOS:000725020300007
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  impact metrics
journal analysis (jcr 2019):
journal impact factor 11.099
5 year journal impact factor 12.503
category normalized journal impact factor percentile 94.524
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