Recent trends on the development of systems for cancer diagnosis and treatment by microfluidic technology

authors	Silva, ACQ; Vilela, C; Santos, HA; Silvestre, AJD; Freire, CSR
nationality	International
journal	APPLIED MATERIALS TODAY
author keywords	Microfluidic technology; Lab-on-a-chip; Cancer diagnosis; Drug delivery systems; Cancer therapy
keywords	CIRCULATING TUMOR-CELLS; DRUG-DELIVERY SYSTEMS; ONE-STEP FABRICATION; LABEL-FREE ISOLATION; POLYMERIC NANOPARTICLES; RECENT PROGRESS; GENEXOL-PM; PHASE-I; CHIP; PLATFORM
abstract	Cancer is the second leading cause of non-accidental death in the world, accounting for roughly 9.6 million deaths in 2018. In the latter years, research in this domain has grown exponentially, as a way to provide deep insights into this malignancy, but also new tools for early diagnosis and efficient personalized treatment options. Microfluidic lab-on-a-chip technology has demonstrated a high potential on the design of new methodologies for cancer diagnosis, treatment and disease follow-up. Here, we present a detailed review on the application of the microfluidic platforms for the detection and separation of tumour cells from blood (liquid biopsy) and the development of new drug delivery systems for cancer conquering. (C) 2019 Elsevier Ltd. All rights reserved.
publisher	ELSEVIER
issn	2352-9407
year published	2020
volume	18
digital object identifier (doi)	10.1016/j.apmt.2019.100450
web of science category	Materials Science, Multidisciplinary
subject category	Materials Science
unique article identifier	WOS:000530651300007