Maria de Fátima Pereira Duarte

Investigador Principal

Perfil biográfico

Interesses científicos

Grupo de Investigação

14- "RefinOlea: Valorização integrada de resíduos e subprodutos da extracção de azeite" a project in ADI Co-promotion (ref. FCOMP-01-0202-FEDER-005450), as part of the research team, CEBAL Coordinator June 2009.

15- "Antiangiogenic potential of Cynara cardunculus extracts in Hepatocellular Carcinoma therapy", Coordinator September 2009.

16- "Removal of cytotoxic chemotherapy compounds from pharmaceutical/hospital wastewaters by combined membrane processing and advanced electro-oxidation treatment" as participant institution (FCT reference:PTDC/AAC-AMB/100960/2008), January 2010.

17- "Anti-angiogenic potential of Cynara cardunculus leaves extracts on human breast cancer cells", ref. CBL/LFD/RP07/2010, Coordinator September 2010.

18- "BIECOS: Valorização Integrada de Biomassa", a QREN project, as member of the research team, Octocber 2010.

19- "Biological characterization of E. grandis x globulus bark lipophilic extractives on human breast cancer cell lines", as part of the European Project AFORE (FP7) coordinated by VTT, as part of the CICECO´s research team, November 2010.

20- "AFORE: Forest biorefineries: Added-value from chemicals and polymers by new integrated separation, fractionation and upgrading technologies", 2009-2013, FP7-NMP-2008-LARGE-2, as part as the research team of WP3, since November 2010

21 - RitecaII - Research network Portugal-Spain - including Extremadura, Centro e Alentejo (Phase II), as part of the research team, CEBAL Coordinator January 2011.

22- "NEW PROTECTION: NativE, Wild PRObiotics sTrain EffeCT in Olives in briNe" as participant institution (FCT reference: PTDC/AGR-ALI/117658/2010), Novembro 2011.

23- "Desenvolvimento da fileira da romã – Da planta ao bago pronto a comer", ref. ProDeR 45071, as part of the research team, June 2013.

24- "NEucBark – new valorization strategies for Eucalyptus spp. bark extracts" as responsible investigator (FCT reference: : PTDC/AGR-FOR/3187/2012), June 2013.

Principais colaboradores

Projectos

Actividade pedagógica

Publicações seleccionadas

Schmitt, F.C., Reis-Filho, J.S., Milanezi, F., Soares, R., Duarte, F., Seixas, C. and Cameselle-Teijeiro, J.F. Pathology of hereditary breast cancer. Revista de Senologia y Patología Mamaria, 2001; 14:29-35.

Duarte, F., Cameselle-Teijeiro, J.F., Soares, R., Seixas, C., Cortizo-Torres, M.E. and Schmitt, F.C., Analysis of mutations in genes BRCA1 and BRCA2 among patients with breast and ovarian cancer in northern Portugal and Galicia. Rev. Clinica. Española, 2002, 202:259-263.

Cortizo-Torres, M.E., Duarte, F., Schmitt, F.C., Cameselle-Teijeiro, J.F. and Lopez-Touza, A., Criteria for definition of hereditary breast cancer in a clinic perspective. The Breast Journal, 2002; 8:402-403.

Cortizo-Torres, M.E., Cameselle-Teijeiro, J.F., López-Touza, A., Duarte, F. and Schmitt, F.C., Chronobiology and Breast Cancer. The Breast Journal, 2003; 9:453-454.

Prudovksy, I., Mandinova, A., Soldi, R., Bagalá, C., Graziani, I., Landriscina, M., Tarantini, F., Duarte, M., Bellum, S., Doherty, H. and Maciag, T. The non-classical export routes: IL1 alpha; and FGF1 and IL1 alpha; point the way. Journal of Cell Science, 2003; 116 (24):4871-4881.

Kolev, K., Kacer, D., Trifonova, R., Small, D., Duarte, M., Soldi, R., Graziani, I., Sideleva, O., Larman, B., Maciag, T. and Prudovsky, I. The intracellular domain of Notch ligand Delta1 induces cell growth arrest. FEBS Lettters 2005; 579:5798-5802.

Graziani, I., Bagalá, C., Duarte, M., Soldi, R., Kolev, K., Tarantini, F., Kumar, T.K.S., Doyle, A., Neivandt, D., Yu, C., Maciag, T., and Prudovsky, I. Release of FGF1 and p40 Synaptotagnin 1 correlates with their membrane destabilizing ability. Biochemical and Biophysical Research Communications, 2006; Oct 13; 349(1):192-198.

Duarte M., Kolev, V., Soldi, R., Kirov, A., Graziani, I., Oliveira, S.M., Kacer, D., Friesel, R., Maciag, T., and Prudovsky, I. Thrombin induces rapid PAR1-mediated non-classical FGF1 release. Biochemical and Biophysical Research Communications, 2006; Nov 24; 350(3):604-9.

Di Serio, C., Pellerito, S., Duarte, M., Massi, D., Naldini, A., Micucci, I., Doria, L., Mirone, P., Cirino, G., Prudovsky, I., Santucci, M., Geppetti, P., Masotti, G., and Tarantini, F. Protease-activated receptor 1-selective antagonist SCH79797 inhibits cell proliferation and induces apoptosis by a protease-activated receptor 1-independent mechanism. Basic & Clinical Pharmacology & Toxicology 2007; 101(1):63-69.

Duarte, M., Longatto Filho, A. and Schmitt, F.C. Angiogenesis, haemostasis and cancer: new paradigms old concerns. Journal Brasileiro de Patologia Médica Laboratorial, Review Paper. 2007; 43(6):441-449.

Soldi, R., Mandinova, A., Venkataraman, K., Hla, T., Vadas, M.A., Pitson, S.M., Duarte, M., Graziani, I., Kolev, K., Kacer, D., Kirov, A., Maciag, T., and Prudovsky, I. Sphingosine Kinase 1 is a critical component of the copper-dependent FGF1 export pathway. Experimental Cell Research 2007; 313(15):3308-3318.

Nikopoulos, G.N., Duarte, M., Kubu, C.J., Bellum, S., Friesel, R., Maciag, T., Prudovsky, I., and Verdi, J.M. Soluble Jagged1 attenuates lateral inhibition allowing for the clonal expansion of neural crest stem cells. Stem Cells. 2007; 25(12):3133-3142.

Longatto Filho, A., Duarte, M. and Schmitt, F.C.Lymphangiogenesis: from the pig embryos to cancer. Journal Brasileiro de Patologia Médica. 2007;44(3):215-220.

Duarte, M., Kolev, V., Kacer, D., Graziani, I., Soldi, R., Maciag, T., and Prudovsky, I. Thrombin cleaves Jagged1, forming a soluble Jagged1 form biologically active. Molecular Biology of the Cell 2008 Nov;19(11):4863-4874.

Mota, I., Pinto, P.C.R, Novo, C., Sousa, G., Guerreiro, O., Guerra, A., Duarte, M.F., and Rodrigues, A. E. Extraction of polyphenolic compounds from Eucalyptus globulus bark: process optimization and screening for biological activity. Industrial & Engineering Chemistry Research 2012 May; 51(20):6991-7000.

Tiburcio, M., Costa, M.A.S., Duarte, M., Schmitt F.C., Longatto Fillho, A. Characterization of PAR1 and FGFR1 Expression in Invasive Breast Carcinomas: Prognostic Significance. Oncology Letters 2012; (4):647-657.

Kirov, A., Duarte, M., Guay, J., Karolak, M., Yan, C., Oxburgh, L., and Prudovsky, I. Transgenic expression of nonclassically secreted FGF suppresses kidney repair. PLoS One. 2012;7(5):e36485. Epub 2012 May 14.

Guerreiro, O., Velez, Z., Alvarenga, N., Matos, C., and Duarte, M. Molecular screening of ovine mastitis in different breeds. J Dairy Science. 2013; 96(2): 752-760.

Velez, Z., Campinho, M.A., Guerra, A., Garcia, L., Ramos, P., Guerreiro, O., Felicio, L., Schmitt, F., Duarte, M., Biological Characterization of Cynara cardunculus L. Methanolic Extracts: Antioxidant, Anti-proliferative, Anti-migratory and Anti-angiogenic Activities. Agriculture. 2012; 2(4): 472-492.

Ramos, P., Santos, S.A.O., Guerra, A.R., Guerreiro, O., Felicio, L., Jerónimo, E., Silvestre, A.J.D., Neto, C.P., Duarte M. Valorisation of olive mill residues antioxidant and breast cancer antiproliferative activities of hydroxytyrosol-rich extracts derived from olive oil by-products. Industrial Crops and Products 2013; (46) 359-368.

Gomes, F.P., Silva, N., Trovatti, E., Serafim L.S., Duarte, M.,Silvestre,A.J.D., Freire C.S.R. Production of Bacterial Cellulose by Gluconacetobacter sacchari using dry olive mill residue. Bioenergy and Biomass. 2013; 55:205-211.

Domingues, R.M.A., Guerra, A.R., Duarte, M., Freire, C.S.R., Neto, C.P., Silva, C.M.S., and Silvestre, A.J.D. Bioactive triterpenic acids: from agroforestry biomass residues, to promising therapeutic tools. Mini-Reviews in Organic Chemistry (in press).

Publicações

Impact of novel SNPs identified in Cynara cardunculus genes on functionality of proteins regulating phenylpropanoid pathway and their association with biological activities

Ferro, AM; Ramos, P; Guerreiro, O; Jeronimo, E; Pires, I; Capel, C; Capel, J; Lozano, R; Duarte, MF; Oliveira, MM; Goncalves, S
2017, BMC GENOMICS, 18, 1.

Lipophilic Fraction of Cultivated Bifurcaria bifurcata R. Ross: Detailed Composition and In Vitro Prospection of Current Challenging Bioactive Properties

Santos, SAO; Trindade, SS; Oliveira, CSD; Parreira, P; Rosa, D; Duarte, MF; Ferreira, I; Cruz, MT; Rego, AM; Abreu, MH; Rocha, SM; Silvestre, AJD
2017, MARINE DRUGS, 15, 11.

Production of bacterial cellulose by Gluconacetobacter sacchari using dry olive mill residue

Gomes, FP; Silva, NHCS; Trovatti, E; Serafim, LS; Duarte, MF; Silvestre, AJD; Neto, CP; Freire, CSR
2013, BIOMASS & BIOENERGY, 55, 205-211.

Valorization of olive mill residues: Antioxidant and breast cancer antiproliferative activities of hydroxytyrosol-rich extracts derived from olive oil by-products

Ramos, P; Santos, SAO; Guerra, AR; Guerreiro, O; Felicio, L; Jeronimo, E; Silvestre, AJD; Neto, CP; Duarte, M
2013, INDUSTRIAL CROPS AND PRODUCTS, 46, 359-368.

Molecular screening of ovine mastitis in different breeds

Guerreiro, O; Velez, Z; Alvarenga, N; Matos, C; Duarte, M
2013, JOURNAL OF DAIRY SCIENCE, 96, 2, 752-760.

Lipophilic Extracts of Cynara cardunculus L. var. altilis (DC): A Source of Valuable Bioactive Terpenic Compounds

Ramos, PAB; Guerra, AR; Guerreiro, O; Freire, CSR; Silva, AMS; Duarte, MF; Silvestre, AJD
2013, JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 61, 35, 8420-8429.

Eucalyptus globulus bark as a source of polyphenolic compounds with biological activity

Da Mota M.I.F., Pinto P.C.O.R., Novo C.C., Sousa G.D.A., Da Neves Guerreiro O.R.F., Da Conceicao Relvas Guerra A., Duarte M.F.P., Rodrigues A.E.
2013, O Papel, 74, 1, 57-64.

Extraction of Polyphenolic Compounds from Eucalyptus globulus Bark: Process Optimization and Screening for Biological Activity

Mota, I; Pinto, PCR; Novo, C; Sousa, G; Guerreiro, O; Guerra, AR; Duarte, MF; Rodrigues, AE
2012, INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH, 51, 20, 6991-7000.

Characterization of PAR1 and FGFR1 expression in invasive breast carcinomas: Prognostic significance

Tiburcio, M; Costa, SMA; Duarte, MD; Schmitt, FC; Longatto, A
2012, ONCOLOGY LETTERS, 4, 4, 647-657.

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