Pedro R. Figueiredo

Estudante de doutoramento

Synthesis of Polycaprolatone by CalB

Education

Experimental Biology and Biomedicine, PhD
University of Coimbra (Coimbra, Portugal)
Ongoing
Thesis: Enzymatic synthesis of amphiphilic polymer-drug conjugates for cancer treatment, Carvalho A.T.P.Silveste A.J.D.; Sousa A.F.
 
Medicinal Chemistry, MSc
University of Minho (Braga, Portugal)
2018 
Dissertation: Studies on the synthesis of adenine derivatives and analogues as anticancer drug candidates, Proença M.F. 
 
Chemistry, BSc
University of Minho (Braga, Portugal)
2015
Dissertation: Synthesis of anthraquinone derivatives (as electrochemical sensors), Proença M.F.; Araújo R.F.

Grants/Projects

Protein Design in Biotechnology and Health
Researcher, 2021 (CPCA/A1/447491/2021)
 
Enzymatic Synthesis of Biopolymeric Conjugates for Advanced and Targeted Therapies
Co-PI Researcher, 2020 (CPCA/A2/4568/2020)
 
Enzymatic Synthesis of Biodegradable Amphiphilic Polymer-drugs for Cancer Treatment
PhD Student Fellow, 2019-present (SFRH/BD/144303/2019)
 
Rational Design of a Thermostable Esterase for the Production of High-value Bioplastics for Biomedical Applications
Research Fellow, 2018-2019 (MIT-EXPL/ISF/0021/2017)

Publicações

Insights into the Degradation of Polymer–Drug Conjugates by an Overexpressed Enzyme in Cancer Cells

Pedro R. Figueiredo, Ricardo D. González, and Alexandra T.P. Carvalho
2023, Journal of Medicinal Chemistry, 66, 4.

Antidotal effect of cyclosporine A against α-amanitin toxicity in CD-1 mice, at clinical relevant doses

Juliana Garcia, Alexandra Carvalho, Ricardo Pires das Neves, Rui Malheiro, Daniela F Rodrigues, Pedro R Figueiredo, Antonio Bovolini, José Alberto Duarte, Vera Marisa Costa, Félix Carvalho
2022, Food and Chemical Toxicology, 166, 113198.

An injectable, naproxen-conjugated, supramolecular hydrogel with ultra-low critical gelation concentration—prepared from a known folate receptor ligand

Carlos BP Oliveira, Sérgio RS Veloso, Elisabete MS Castanheira, Pedro R Figueiredo, Alexandra TP Carvalho, Loic Hilliou, Renato B Pereira, David M Pereira, José A Martins, Paula MT Ferreira, Peter J Jervis
2022, Soft Matter, 18, 20, 3955-3966.

Development of Enzymatic Variants for the Synthesis of Bioresorbable Polyesters

Almeida, BC; Figueiredo, PR; Dourado, DFAR; Paul, S; Sousa, AF; Silvestre, AJD; Quinn, DJ; Moody, TS; Carvalho, ATP
2022, ORGANIC PROCESS RESEARCH & DEVELOPMENT, 26, 8, 2351-2363.

Introduction of a Glycine Linker Connecting the Heavy and Light Chains in Synthetic Cardosin B-Derived Rennet Changes the Specificity of Subpocket S3′

Pedro R. Figueiredo, Sónia F.G. Santos, Beatriz C. Almeida, Isaura Simões and Alexandra T. P. Carvalho
2021, The Journal of Physical Chemistry B.

Transcription factor allosteric regulation through substrate coordination to zinc

Beatriz C. Almeida, Jennifer Kaczmarek, Pedro R. Figueiredo, Kristala L. Jones Prather and Alexandra T.P. Carvalho
2021, NAR Genomics and Bioinformatics.

Human Carboxylesterase 2 in Cocaine Metabolism

Pedro R.Figueiredo, Ricardo D.González, Alexandra T.P.Carvalho
2021, Molecular Catalysis, 515.

Enzymatic Synthesis of Poly(caprolactone): A QM/MM Study

Pedro R. Figueiredo, Beatriz C. Almeida, Daniel F. A. R. Dourado, Andreia F. Sousa, Armando J. D. Silvestre and Alexandra T. P. Carvalho
2020, ChemCatChem, 12, 19, 4845-4852.
ISBN: 1867-3899

Polycaprolactone Enzymatic Hydrolysis: A Mechanistic Study

Beatriz C. Almeida, Pedro Figueiredo and Alexandra T. P. Carvalho
2019, ACS Omega, 4, 4.

Enzymatic Polymerization of PCL-PEG co-polymers for Biomedical Applications

Pedro Figueiredo, Beatriz C. Almeida and Alexandra T. P. Carvalho
2019, Frontiers in Molecular Biosciences, 6.

From common plastics to sustainable alternatives: A mechanistic study of a green catalyst

Beatriz C. Almeida; Figueiredo, Pedro; Alexandra T. P. Carvalho
2019.

Enzymatic transesterification of PCL-PEG co-polymers

Figueiredo, Pedro; Beatriz C. Almeida; Alexandra T. P. Carvalho
2019.

Rational design of enzymatic production of high-value biodegradable polymers

Almeida, Beatriz C.; Pedro Figueiredo; Alexandra T. P. Carvalho
2019.

Enzymatic synthesis of poly(e-caprolactone): a QM/MM MD study

Figueiredo, Pedro; Almeida, Beatriz C.; Carvalho, Alexandra T. P.
2019.

Rational design of enzymatic production of high-value biodegradable polymers for biomedical applications

Alexandra T. P. Carvalho; Pedro R. Figueiredo; Almeida, Beatriz C.
2019.

Synthesis of poly(e-caprolactone): a bio-based polymer for biomedical applications

Figueiredo, Pedro; Almeida, Beatriz C.; Carvalho, Alexandra T. P.
2019.

Rational design of enzymatic production of high value biodegradable polymers for biomedical applications

Almeida, Beatriz C.; Figueiredo, Pedro; Alexandra T. P. Carvalho
2019.

Catalytic cycle of CALB towards the synthesis of poly(e-caprolactone)

Figueiredo, Pedro; Carvalho, Alexandra
2019.

Rational design of enzymes for biopolymer synthesis

Alexandra T. P. Carvalho; Pedro R. Figueiredo; Almeida, Beatriz C.
2019.

Rational design of esterases for biopolymer synthesis

Pedro R. Figueiredo, Beatriz C. Almeida, Alexandra T. P. Carvalho
2019.

Synthesis and characterization of new perylenediimides functionalized with dehydroamino acid

Figueiredo, Pedro; Proença, Maria Fernanda; Martins, José Alberto
2016.

Síntese de perilenobisimidas modificadas com derivados de antraquinona e ferroceno (para posterior aplicação como sensores electroquímicos)

Figueiredo, Pedro; Proença, Maria Fernanda
2016.

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