Permeation of skin with (C-60) fullerene dispersions

resumo

Dispersions in transcutol/isopropylmyristate make C-60 fullerenemolecules suitable for transdermal delivery. We found that C-60 can successfully permeate the skin using pig skin in Franz diffusion cells. Molecular dynamics simulations and transmission electron microscopy confirmed these observations. Basic cosmetic formulations with transcutol/isopropylmyristate without harsh organic solvents show a high potential for delivery of C-60 for biopharmaceutical and cosmetics applications.

palavras-chave

IN-VITRO; PERCUTANEOUS-ABSORPTION; TRANSDERMAL PERMEATION; LIPID-PEROXIDATION; MOLECULAR-DYNAMICS; STRATUM-CORNEUM; SOLUBILITY; MODEL; PIG; NANOMATERIALS

categoria

Biotechnology & Applied Microbiology

autores

Martins, M; Azoia, NG; Melle-Franco, M; Ribeiro, A; Cavaco-Paulo, A

nossos autores

agradecimentos

This study was supported by the Portuguese Foundation for Science and Technology (FCT) under the scope of the strategic funding of UID/BIO/04469/2013 unit and COMPETE 2020 (POCI-01-0145-FEDER-006684).). Artur Ribeiro thanks FCT for the SFRH\BPD\98388\2013 grant.

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