Ag2S Nanoheaters with Multiparameter Sensing for Reliable Thermal Feedback during In Vivo Tumor Therapy


The emergence of luminescence nanothermometry in bio and nanomedicine has enabled achievements outside the reach of conventional techniques. For instance, it has provided real-time monitoring of in vivo thermal therapies of tumors, a mandatory requirement for these techniques to work safely and efficiently. However, the reliability of intratumoral thermal readings is currently in question due to the presence of artefacts caused by the inhomogeneous optical properties of biological tissues. This work demonstrates how it is possible to avoid, under specific conditions, these artefacts and reach precise and reliable in vivo intratumoral thermal feedback during in vivo photothermal treatments. The method proposed is based on the use of luminescent nanoparticles capable of multiparametric thermal sensing. The results demonstrate how the convergence of the different thermal readouts becomes a solid indicator of their reliability. It is shown how this new approach makes possible precise (thermal uncertainties below 1 degrees C) intratumoral thermal feed-back, while simple, efficient, and minimally invasive in vivo thermal treatments of surface tumors is carried out. Results included in this work provide an ingenious route toward the consolidation of luminescence nanothermometry as a convincing technique for high sensitivity preclinical thermal sensing, while also constituting a step toward improved photothermal therapies.




Chemistry; Science & Technology - Other Topics; Materials Science; Physics


Shen, YL; Santos, HDA; Ximendes, EC; Lifante, J; Sanz-Portilla, A; Monge, L; Fernandez, N; Coria, IC; Jacinto, C; Brites, CDS; Carlos, LD; Benayas, A; Iglesias-de la Cruz, MC; Jaque, D



Y.S., H.D.A.S., and E.C.X. contributed equally to this work. This work has been founded by Ministerio de Economia y Competitividad-MINECO (MAT2016-75362-C3-1-R), by the Ministerio de Ciencia e Innovacion de Espana (PID2019-106211RB-I00), the Comunidad de Madrid (B2017/BMD-3867 RENIM-CM) co-financed by European Structural and Investment Fund and by the European Union's Horizon 2020 FET Open programme under grant agreement No 801305 (NanoTBTech). C.D.S.B. and L.D.C. thanks the project CICECO-Aveiro Institute of Materials, UIDB/50011/2020 & UIDP/50011/2020, financed by Portuguese funds through the Portuguese Foundation for Science and Technology (FCT)/MCTES. Y.S. acknowledges the support from the China Scholarship Council (CSC No. 201806870023). A.B. thanks the European Commission as his participation in this project at its later stage received funding from the European Union's Horizon 2020 research and innovation programme under the Marie Skodowska Curie Grant Agreement No. 709270 TEMPTATION. E.C.X. is grateful for a Juan de la Cierva Formacion scholarship (FJC2018-036734-I). C.J. thanks the financial support of the Brazilian agencies: CNPq (Conselho Nacional de Desenvolvimento Cientifico e Tecnologico) through the grants: Projeto Universal Nr. 431736/2018-9 and Scholarship in Research Productivity 1C under the Nr. 304967/20181; FAPEAL (FundacAo de Amparo a Pesquisa do Estado de Alagoas) grant Nr. 1209/2016. H.D.A.S. was supported by a graduate studentship from CNPq and by a sandwich doctoral program (PDSE-CAPES) developed at Universidad Autonoma de Madrid, Spain, Project Nr. 88881/2016-01.

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