Histidine-based hydrogels via singlet-oxygen photooxidation
authors Liberato, MS; Cavalcante, NGS; Sindu, PA; Rodrigues-Jesus, MJ; Zelenovskii, P; Carreira, ACO; Baptista, MS; Sogayar, MC; Ferreira, LCS; Catalani, LH
nationality International
journal SOFT MATTER
keywords CROSS-LINKING; MECHANICAL-PROPERTIES; STABILITY; POLYMER; COMPOSITES; PROTEINS; DNA
abstract The formation of hydrogels by photosensitized oxidation and crosslinking of histidine-derived polymers is demonstrated for the first time. The photooxidation of pendant His mediated by singlet oxygen was used to promote covalent coupling by its dimerization. As a proof-of-concept, two systems were studied: (i) chondroitin sulfate (CS) functionalized with His, and (ii) an elastin-like peptide (ELP) containing His produced by recombinant techniques. Both materials were crosslinked by irradiation at 425 nm in the presence of Zn-porphyrin derivatives yielding His-based hydrogels. The molecular structure and physicochemical properties of ELP-His and other 5 ELPs with photooxidizable amino acids were studied in silica by computer simulation. A correlation between the protein conformation and its elastic properties is discussed. CS-His hydrogels demonstrate larger storage moduli than ELPs with other amino acids. The obtained results show the potential use of photooxidation to create a new type of His-based hydrogels.
publisher ROYAL SOC CHEMISTRY
issn 1744-683X
isbn 1744-6848
year published 2021
volume 17
issue 48
beginning page 10926
ending page 10934
digital object identifier (doi) 10.1039/d1sm01023a
web of science category 9
subject category Chemistry, Physical; Materials Science, Multidisciplinary; Physics, Multidisciplinary; Polymer Science
unique article identifier WOS:000721381900001
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