Swelling and Release Properties of Functional kappa-carrageenan Hydrogel Nanocomposites
authors da Silva, ALD; Salgueiro, AM; Fateixa, S; Moreira, J; Estrada, AC; Gil, AM; Trindade, T
editors Lendlein, A; Behl, M; Feng, Y; Guan, Z; Xie, T
nationality International
keywords MECHANISM
abstract Today polysaccharide based hydrogel nanocomposites are receiving high importance as biomaterials for drug delivery. Inorganic nanoparticles (NPs) are incorporated into the polymer matrix to provide novel functionalities to the hydrogels. However, the effect of nanofillers on the release properties has not been totally understood. In this work, we investigate the influence of inorganic functional nanofillers (Fe3O4 and Au NPs) with variable size and shape on the structure of.-carrageenan hydrogels and on the kinetics and release mechanism of methylene blue (MB) as model drug. It was shown that, depending on the nature of the nanofiller incorporated, and for equivalent nanofiller content, the mechanism of MB release can be adjusted either to by diffusion or polymer relaxation mechanism. The mechanism of the MB release was found to be determined by the strength and microstructure of the gel network and extent of gel swelling, which are affected by the extent of incorporation of the nanofillers.
issn 0272-9172
isbn 978-1-60511-380-7
year published 2012
volume 1403
beginning page 213
ending page 219
digital object identifier (doi) 10.1557/opl.2012.421
web of science category Materials Science, Characterization & Testing; Polymer Science
subject category Materials Science; Polymer Science
unique article identifier WOS:000309561200032