Ildefonso Marin Montesinos

Junior Researcher

Contact

Department

  • Chemistry
  • 15.3.20

Research

Links

Latest News

Scientic Interests

Methodology

  • Methodology in solid-state NMR and Magic-Angle Spinning Dynamic Nuclear Polarization (MAS-DNP) techniques
  • Developing of protocols  and novel radicals for MAS-DNP
  • Dipolar recoupling techniques by symmetry-based pulse sequences
  • Other characterization techniques: Neutron scattering and reflectometry, QCMd, AFM, ellipsometry, XRD, FT-IR, Langmuir-Blodgett isotherms, volumetric adsorption analysis, thermogravimetric analysis.
  • Sample preparation of lipidic samples: Langmuir-Blodgett film formation and liposome formation techniques

Materials

  • Characterization of materials for gas capture applications
  • Characterization of materials for application in catalysis
  • Novel materials from different waste for gas adsorption
  • Novel Materials for CO2 adsorption/conversion

Biology

  • Protein-Ligand interactions
  • Interaction site structure in protein-ligand binding
  • Characterization and study of membrane associated processes and biomolecules
  • Antimicrobial peptides
  • MAS-DNP and NMR characterization of biological systems
  • Structural study of the interaction interfaces of adaptor proteins involved in clathrin-mediated endocytosis (CME)
  • CME and its implications in degenerative diseases

Short CV

ACADEMIC BACKGROUND

I obtained my BSc. in Chemistry at the Universidad de Sevilla in 2001. By October 2003, I started a PhD funded by an EPSRC Grant in the development of recoupling methods in Solid-State NMR for biomolecules in the group of Malcolm H. Levitt (University of Southampton). RESEARCH CAREER In November 2007, I joined the group of Ulrich Günther (University of Birmingham) as post-doc, where I entered in contact for the first time with the Dynamic Nuclear Polarization (DNP) technique. In 2010, I obtained the Beatriu de Pinós and Juan de La Cierva grants to work at the Biomolecular NMR Laboratory with Miquel Pons (IRB-Barcelona and the Universitat de Barcelona). In this lab, I started building my network of collaborators, further strengthening my knowledge of DNP and protein-ligand interactions. From 2015-2018, I was awarded a Labex ARCANE Postdoctoral Fellowship in the laboratory of Gaël de Paëpe and Sabine Hediger (CEA-Grenoble and Université Grenoble-Alpes). This position allowed me to further improve my knowledge of DNP by working in the study of carbohydrate-protein interaction by Magic-Angle-Spinning DNP (MAS-DNP) solid-state NMR in lectins. In 2019, I joined CICECO-Aveiro Institute of Materials as a researcher to work in the team of Luis Mafra using NMR and MAS-DNP for the characterization of porous materials and biomaterials with multiple applications such as gas separation/capture and catalysis. Additionally, I am establishing my own independent research line on structural biology with two main projects (see below).

CURRENT RESEARCH LINES

a) Biochemistry/Biology:

  1. Study interaction interfaces in clathrin-mediated endocytosis using complementary characterization techniques (solid-state NMR, neutron reflectometry, QCMD)
  2. Study the interaction of antimicrobial peptides with mimetic membranes
  3. Brewer spent yeast glucan structural characterization and its role on receptor recognition

b) Porous materials for CO2 capture:

  1. Amine-modified silicas
  2. Valorization of industrial bioresidues
  3. Covalent Organic Frameworks
  4. Periodic mesoporous organo-silicas
  5. Polysaccharide-derived solid CO2
  6. Lithium silicate sorbents. Different studies are performed for the characterization of these materials for CO2 capture. Amongst others, adsorption isotherms, NMR/DNP experiments for speciation and quantification, degradation under different conditions of humidity and temperature and recyclability assays.

c) NMR/DNP methodological developments:

  1. 3D-printing of NMR probe components.
  2. New radicals and sample formulation for MAS-DNP in porous materials and lipid membranes.

Research group

Team Specko: http://specko.web.ua.pt

 

Ongoing Supervisions

Andrea Chacón Calderón

PhD Student

Márcio Miguel da Silva Soares

PhD Student

Tiago Fernando Teixeira Morais

PhD Student

Vítor J. Martins

PhD Student

Publications

Improved stability and spectral quality in ex situ Dissolution-DNP using and improved transfer device

S. Katsikis, I. Marín-Montesinos, M. Pons, C. Ludwig and U. Günther
2015, Applied Magnetic Resonance, 46, 723.

Self-assembled trityl radical capsules. Implications for Dynamic Nuclear Polarization

I. Marín-Montesinos, J.C. Paniagua, M. Vilaseca, Ainhoa Urtizberea, Fernando Luís, M. Feliz, Feng Lin, S. Van Doorslaer and M. Pons
2015, Physical Chemistry Chemical Physics, 17, 5785.

Novel PTM-TEMPO biradical for Fast Dissolution Dynamic Nuclear Polarization

J.L. Muñoz-Gómez, I. Marín-Montesinos, V. Lloveras, M. Pons, J. Vidal-Gancedo and J. Veciana
2014, Organic Letters, 16, 5402.

Long-lived states in an intrinsically disordered protein domain

L. Fernandes, C. Guerniou, I. Marín-Montesinos, M. Pons, F. Kateb and P.R. Vasos
2013, Magnetic Resonance in Chemistry, 51, 729.

Optimizing the Polarization Matrix for ex Situ Dynamic Nuclear Polarization

C. Ludwig*, I. Marin-Montesinos*, M. Saunders, and U. Günther
2010, Journal of the American Chemical Society, 132, 2508.

Quantum Rotor Induced Hyperpolarization

M. Saunders, C. Ludwig, I. Marin-Montesinos and U. Günther,
2010, Proceedings of the National Academy of Sciences , 107, 10799.

Application of ex situ dynamic nuclear polarization in studying small molecules

C.Lugwid, I. Marin-Montesinos, M. G. Saunders, A.H. Emwas, Z. Pikramenou, S.P. Hammond, U.L. Günther
2010, Physical Chemistry Chemical Physics , 12, 5868.

Light Penetration and Photoisomerization in Rhodopsin studied by Numerical Simulations and Double - Quantum Solid - State NMR

M. Concistrè, A. Gansmüller, N. McLean, O. G. Johannessen, I. Marín Montesinos, P. H. M. Bovee- Geurts, R. C. D. Brown, W. J. DeGrip and M. H. Levitt,
2009, Journal of the American Chemical Society, 131, 6133.

Towards an interpretation of 13C chemical shifts in bathorhodopsin, a functional intermediate of a G-protein coupled receptor

A. Gansmüller, M. Concistrè, N. McLean, O. G. Johannessen, I. Marín Montesinos, P. H. M. Bovee- Geurts, P. Verdegem, J. Lugtenburg, R. C. D. Brown, W. J. DeGrip and M. H. Levitt
2009, Biochimica et Biophysica Acta, 1788, 1350 .

Double-Quantum 13C Nuclear Magnetic Resonance of Bathorhodopsin, the First Photointermediate in Mammalian Vision

M. Concistrè, A. Gansmüller, N. McLean, O. G. Johannessen, I. Marín Montesinos, P. H. M. Bovee- Geurts, P. Verdegem, J. Lugtenburg, R. C. D. Brown, W. J. DeGrip and M. H. Levitt
2008, Journal of the American Chemical Society, 130, 10490 .

We use cookies for marketing activities and to offer you a better experience. By clicking “Accept Cookies” you agree with our cookie policy. Read about how we use cookies by clicking "Privacy and Cookie Policy".


Privacy and Cookie Policy

Personal data

CICECO-Aveiro Institute of Materials respects your privacy, ensuring confidentiality of personal data you share with the institution through this way, not collecting any personal information about you without your consent, under the terms required by General Data Protection Regulations (RGPD).

The data collected in forms are intended exclusively for processing user requests and will not be used for any other purpose, always safeguarding their confidentiality, under the terms of the protection conferred by the aforementioned regulation.

The collection and processing of data is the responsibility of CICECO and its storage is properly protected, only authorized CICECO employees can access the information within the scope of their functions, always being clear in the respective collection forms the purposes for which they are intended. The remaining issues to be considered in this matter will be handled by the University of Aveiro in accordance with the regime established by the GDPR.

Cookies policy

Cookies are small files with alphanumeric information that are stored on your computer's hard drive by your browser and are intended to improve the user experience and enhance website navigation.

Collection and use of technical information

The cookies used on CICECO are anonymous, and no information about our users that allows their personal identification is stored in them.

The technical information recorded consists of:

  • iP (Internet Protocol) address of the visitor;
  • the type of internet browser used by the website visitor and the respective operating system used;
  • the date and time of the consultation;
  • the pages visited on the site and the documents downloaded
  • The technical information collected is used for statistical purposes only.

Cookies used

Session cookies

These cookies are used to record user preferences, such as the language in which websites are displayed or to maintain authenticated user sessions, and are automatically deleted when the browser is closed.

Persistent cookies

These cookies store information that is needed between sessions. For example, a persistent cookie is set to record that you have been made aware of the cookie policy so that the message regarding this policy is not shown again the next time you visit the website. This cookie remains on the computer until it reaches its expiry date or is deleted by the user.

Data protection

The present privacy policy covers the Information System of the University of Aveiro (SIUA), governed by the General Data Protection Regulations (RGPD) Regulation (EU) No. 2016/679, of April 27th, 2016.

Data Protection Officer

The University of Aveiro has a Data Protection Officer (DPO), who ensures compliance of the processing of personal data with the legislation in force, and is available through the following email address epd@ua.pt.

Close