João Henrique Picado Madalena Santos

PhD Student

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Department

  • Chemistry

Research

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Short CV

Born on 22 of June of 1991 at Aveiro, Portugal, João Santos obtained her MSc degree in Biotechnology from University of Aveiro, Portugal, in 2014. During his graduation Santos was awarded with a research grant (Santander-Universities Scholarship Programme) and in the last year of the MSc studies joined to the Process and Product Applied Thermodynamics (PATh) research group, where he developed her MSc thesis within the topic "Designing new downstream processes based in FPLC and ABS methodologies”. João Santos is currently a PhD student in Chemical Engineering at the University of Aveiro, Portugal, working on the development of novel downstream processes using aqueous biphasic systems technology and in the PEGylation field for biopharmaceutical and biosensing proposes. In his PhD he is working in close colaboration with Pharmaceutical Sciencies Department at University of São Paulo (USP), conducted a 1-year period of exchange at Laboratory of Nanobiotechnology in USP. 

Publications

An integrated process combining the reaction and purification of PEGylated proteins

Santos, JHPM; Mendonca, CMN; Silva, ARP; Oliveira, RPS; Pessoa, A; Coutinho, JAP; Ventura, SPM; Rangel-Yagui, CO
2019, GREEN CHEMISTRY, 21, 23, 6407-6418.
ISBN: 1463-9270

Novel site-specific PEGylated L-asparaginase

Meneguetti, GP; Santos, JHPM; Obreque, KMT; Barbosa, CMV; Monteiro, G; Farsky, SHP; de Oliveira, AM; Angeli, CB; Palmisano, G; Ventura, SPM; Pessoa, A; Rangel-Yagui, CD
2019, PLOS ONE, 14, 2.

PEGylation as an efficient tool to enhance cytochrome c thermostability: a kinetic and thermodynamic study

Santos, JHPM; Carretero, G; Ventura, SPM; Converti, A; Rangel-Yagui, CO
2019, JOURNAL OF MATERIALS CHEMISTRY B, 7, 28, 4432-4439.
ISBN: 2050-7518

Development of L-Asparaginase Biobetters: Current Research Status and Review of the Desirable Quality Profiles

Brumano, LP; da Silva, FVS; Costa-Silva, TA; Apolinario, AC; Santos, JHPM; Kleingesinds, EK; Monteiro, G; Rangel-Yagui, CD; Benyahia, B; Pessoa, A
2019, FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY, 6.

In situ purification of periplasmatic L-asparaginase by aqueous two phase systems with ionic liquids (ILs) as adjuvants

Santos, JHPM; Flores-Santos, JC; Meneguetti, GP; Rangel-Yagui, CO; Coutinho, JAP; Vitolo, M; Ventura, SPM; Pessoa, A
2018, JOURNAL OF CHEMICAL TECHNOLOGY AND BIOTECHNOLOGY, 93, 7, 1871-1880.

Separation of phenolic compounds by centrifugal partition chromatography

Santos, JHPM; Almeida, MR; Martins, CIR; Dias, ACRV; Freire, MG; Coutinho, JAP; Ventura, SPM
2018, GREEN CHEMISTRY, 20, 8, 1906-1916.

Aqueous biphasic systems in the separation of food colorants

Santos, JHPM; Capela, EV; Boal-Palheiros, I; Coutinho, JAP; Freire, MG; Ventura, SPM
2018, BIOCHEMISTRY AND MOLECULAR BIOLOGY EDUCATION, 46, 4, 390-397.

Fractionation of Isochrysis galbana Proteins, Arabinans, and Glucans Using Ionic-Liquid-Based Aqueous Biphasic Systems

Santos, JHPM; Trigo, JP; Maricato, E; Nunes, C; Coimbra, MA; Ventura, SPM
2018, ACS SUSTAINABLE CHEMISTRY & ENGINEERING, 6, 11, 14042-14053.

Protein PEGylation for the design of biobetters: from reaction to purification processes

Santos, JHPM; Torres-Obreque, KM; Meneguetti, GP; Amaro, BP; Rangel-Yagui, CO
2018, BRAZILIAN JOURNAL OF PHARMACEUTICAL SCIENCES, 54.

Heterologous expression and purification of active L-asparaginase I of Saccharomyces cerevisiae in Escherichia coli host

Santos, JHPM; Costa, IM; Molino, JVD; Leite, MSM; Pimenta, MV; Coutinho, JAP; Pessoa, A; Ventura, SPM; Lopes, AM; Monteiro, G
2017, BIOTECHNOLOGY PROGRESS, 33, 2, 416-424.

Designing new downstream processes based in FPLC and ABS methodologies

JOÃO HENRIQUE PICADO MADALENA SANTOS
2014, supervised by Osvaldo Pessoa Jr; Sónia Patrícia Marques Ventura; .

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