Education:
- PhD in Chemistry, Instituto Superior Técnico, Lisbon, Portugal (1993)
- Graduated in Applied Chemistry (Organic Chemistry), Faculdade de Ciências e Tecnologia - Universidade Nova de Lisboa, Lisbon, Portugal (1986)
Academic Career:
- Associate Professor with Aggregation (2008-present)
- Associate Professor (2000-2008)
- Auxiliary Professor(1997-2000)
- Auxiliary Invited Professor (1994-1997)
- Assistant Professor (1993-1994)
- Visiting Scientist at University of Reading, with Professor Michael Drew (1994 and 2001)
Researcher ID
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The research field of our modelling group includes both experimental and computational areas of supramolecular chemistry, in the following research lines
Computer modelling of drug-biological target interactions;

Theoretical investigation of halogen bonds in interlocked and/or macrocyclic receptors;

Molecular design of artificial receptors for anion recognition;

Computational studies of the diffusion of delivery-systems in cellular membrane models.

The computational research includes mainly quantum calculations and molecular dynamics simulations. The experimental structural studies are carried out primarily through single crystal X-ray diffraction using a CCD system. Our group is currently hosted at the Department of Health Sciences.
Most of these research topics are part of our extensive international scientific network (more details bellow).
Further information about our group can be found at the Molecular Modeling Group site.
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- S. J. Moore, C. J. E. Haynes, J. Gonzalez, J. L. Sutton, S. J. Brooks, M. E. Light, J. Herniman, G. J. Langley, V. Soto-Cerrato, R. Perez-Tomas, I. Marques, P. J. Costa, V. Felix and P. A. Gale, Chem. Sci., 2013, 4, 103-117.[link]
- F. Zapata, A. Caballero, N. G. White, T. D. Claridge, P. J. Costa, V. Felix and P. D. Beer, J. Am. Chem. Soc., 2012, 134, 11533-11541.[link]
- A. I. Vicente, J. M. Caio, J. Sardinha, C. Moiteiro, R. Delgado and V. Felix, Tetrahedron, 2012, 68, 670-680.[link]
- J. D. Ingram, P. J. Costa, H. Adams, M. D. Ward, V. Felix and J. A. Thomas, Inorg. Chem., 2012, 51, 10483-10494.[link]
- C. J. E. Haynes, S. J. Moore, J. R. Hiscock, I. Marques, P. J. Costa, V. Felix and P. A. Gale, Chem. Sci., 2012, 3, 1436-1444.[link]
- A. Caballero, F. Zapata, N. G. White, P. J. Costa, V. Felix and P. D. Beer, Angew. Chem. Int. Ed. Engl., 2012, 51, 1876-1880.[link]
- C. J. Serpell, N. L. Kilah, P. J. Costa, V. Felix and P. D. Beer, Angew. Chem. Int. Ed. Engl., 2010, 49, 5322-5326.[link]
- S. M. Santos, P. J. Costa, M. D. Lankshear, P. D. Beer and V. Felix, J. Phys. Chem. B, 2010, 114, 11173-11180.[link]
- N. M. Micaelo, A. L. Macedo, B. J. Goodfellow and V. Felix, J. Mol. Graph. Model., 2010, 29, 396-405.[link]
- C. Cruz, V. Calisto, R. Delgado and V. Felix, Chem. Eur. J., 2009, 15, 3277-3289.[link]
- M. D. Lankshear, I. M. Dudley, K. M. Chan, A. R. Cowley, S. M. Santos, V. Felix and P. D. Beer, Chem. Eur. J., 2008, 14, 2248-2263.[link]
- H. Adams, P. J. Costa, M. Newell, S. J. Vickers, M. D. Ward, V. Felix and J. A. Thomas, Inorg. Chem., 2008, 47, 11633-11643.[link]
- C. Cruz, R. Delgado, M. G. Drew and V. Felix, J. Org. Chem., 2007, 72, 4023-4034.[link]
- V. Felix, M. G. Drew, P. R. Webber and P. D. Beer, Phys. Chem. Chem. Phys., 2006, 8, 521-532.[link]
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Professor Paul D. Beer [link]
Inorganic Chemistry, Department of Chemistry
University of Oxford
Professor Jim A. Thomas [link]
Reader in Coordination Chemistry
University of Sheffield
Professor Phil A Gale [link]
Head of Chemistry, Professor of Supramolecular Chemistry
University of Southampton
Doctor Roberto Quesada [link]
Departamento de Química de la Facultad de Ciencias
Universidad de Burgos
Professor Raj Pal Sharma [link]
Department of Chemistry
University of Panjab
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Doutora Cristina Moiteiro [link]
Departamento de Química e Bioquímica
Univeridade de Lisboa - Faculdade de Ciências
Doutora Paula Brandão [link]
Departamento de Química
Universidade de Aveiro
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Hydrazones in anion transporters: the detrimental effect of a second binding siteMartinez-Crespo, L; Halgreen, L; Soares, M; Marques, I; Felix, V; Valkenier, H 2021, ORGANIC & BIOMOLECULAR CHEMISTRY, 19, 38, 8324-8337.
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Hydrosulfide (HS-) Recognition and Sensing in Water by Halogen Bonding HostsMitchell, EJ; Beecroft, AJ; Martin, J; Thompson, S; Marques, I; Felix, V; Beer, PD 2021, ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 60, 45, 24048-24053.
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Synthesis, characterization, X-ray crystal structure and antibacterial activity of bis[3-(4-chloro-N,N-diethylpyridine-2-carboxamide)] diselenideDhau, JS; Singh, A; Brandao, P; Felix, V 2021, INORGANIC CHEMISTRY COMMUNICATIONS, 133,
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New heptacoordinate tungsten(II) complexes with ?-diimine ligands in the catalytic oxidation of multifunctional olefinsVasconcellos-Dias, M; Nunes, CD; Felix, V; Brandao, P; Calhorda, MJ 2021, INORGANICA CHIMICA ACTA, 519,
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Development of a Library of Thiophene-Based Drug-Like Lego Molecules: Evaluation of Their Anion Binding, Transport Properties, and CytotoxicityVieira, P; Miranda, MQ; Marques, I; Carvalho, S; Chen, LJ; Howe, ENW; Zhen, C; Leung, CY; Spooner, MJ; Morgado, B; Silva, OABDE; Moiteiro, C; Gale, PA; Felix, V 2020, CHEMISTRY-A EUROPEAN JOURNAL, 26, 4, 888-899.
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A polynuclear Cu(ii) complex for real time monitoring of mitochondrial cytochromeCrelease during cellular apoptosisKhanra, S; Ta, S; Paladhi, A; Ghosh, M; Ghosh, S; Hira, SK; Manna, PP; Brandao, P; Felix, V; Das, D 2020, CHEMICAL COMMUNICATIONS, 56, 48, 6563-6566.
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Lipidomic analysis of human primary hepatocytes following LXR activation with GW3965 identifies AGXT2L1 as a main target associated to changes in phosphatidylethanolamineSantinha, D; Klopot, A; Marques, I; Ellis, E; Jorns, C; Johansson, H; Melo, T; Antonson, P; Jakobsson, T; Felix, V; Gustafsson, JA; Domingues, MR; Mode, A; Helguero, LA 2020, JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, 198,
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The Green Box: An Electronically Versatile Perylene Diimide Macrocyclic Host for FullerenesBarendt, TA; Myers, WK; Cornes, SP; Lebedeva, MA; Porfyrakis, K; Marques, I; Felix, V; Beer, PD 2020, JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 142, 01-Jan, 349-364.
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X-ray structurally characterized Mo (VI), Fe (III) and Cu (II) complexes of amide-imine conjugate: (bio)catalytic and histidine recognition studiesTa, S; Ghosh, M; Salam, N; Das, J; Islam, M; Brandao, P; Felix, V; Sanmartin, J; Das, D 2020, APPLIED ORGANOMETALLIC CHEMISTRY, 34, 10,
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Molybdenum(ii) complexes with p-substituted BIAN ligands: synthesis, characterization, biological activity and computational studyQuintal, S; da Silva, MJP; Martins, SRM; Sales, R; Felix, V; Drew, MGB; Meireles, M; Mourato, AC; Nunes, CD; Saraiva, MS; Machuqueiro, M; Calhorda, MJ 2019, DALTON TRANSACTIONS, 48, 23, 8449-8463.
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Exploring aggregation-induced emission through tuning of ligand structure for picomolar detection of pyreneGhosh, M; Ta, S; Lohar, S; Das, S; Brandao, P; Felix, V; Das, D 2019, JOURNAL OF MOLECULAR RECOGNITION, 32, 5,
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Anion Recognition in Water by Charge-Neutral Halogen and Chalcogen Bonding Foldamer ReceptorsBorissov, A; Marques, I; Lim, JYC; Felix, V; Smith, MD; Beer, PD 2019, JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 141, 9, 4119-4129.
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Fluorinated synthetic anion carriers: experimental and computational insights into transmembrane chloride transportSpooner, MJ; Li, HY; Marques, I; Costa, PMR; Wu, X; Howe, ENW; Busschaert, N; Moore, SJ; Light, ME; Sheppard, DN; Felix, V; Gale, PA 2019, CHEMICAL SCIENCE, 10, 7, 1976-1985.
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New Molybdenum(II) Complexes with alpha-Diimine Ligands: Synthesis, Structure, and Catalytic Activity in Olefin EpoxidationVasconcellos-Dias, M; Marreiros, J; Sales, R; Felix, V; Brandao, P; Nunes, CD; Calhorda, MJ 2019, MOLECULES, 24, 3,
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Optical sensors for detection of nano-molar Zn2+ in aqueous medium: Direct evidence of probe- Zn2+ binding by single crystal X-ray structuresMahiuddin, M; Banerjee, M; Shaikh, A; Shyam, T; Taniya, S; Ghosh, A; Adhikary, A; Brandao, P; Felix, V; Das, D 2019, JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY, 368, 52-61.
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