resumo
The interaction of the self-assembled trinuclear ruthenium bowl 1(3+), that displays three other accessible oxidation states, with oxo-anions is investigated. Using a combination of NMR and electrochemical experimental data, estimates of the binding affinities of 1(4+), 1(5+), and 1(6+) for both halide and oxo-anions were derived. This analysis revealed that, across the range of oxidation states of the host, both high anion binding affinities (>10(9) M-1 for specific guests bound to 1(6+)) and high selectivities (a range of >10(7) M-1) were observed. As the crystal structure of binding of the hexafluorophosphate anion revealed that the host has two potential binding sites (named the alpha and beta pockets), the host-guest properties of both putative binding sites of the bowl, in all of its four oxidation states, were investigated through detailed quantum-based computational studies. These studies revealed that, due to the interplay of ion-ion interactions, charge-assisted hydrogen-bonding and anion-pi interactions, binding to the alpha pocket is generally preferred, except for the case of the relatively large and lipophilic hexafluorophosphate anionic guest and the host in the highest oxidation states, where the beta pocket becomes relatively favourable. This analysis confirms that host-guest interactions involving structurally complex supramolecular architectures are driven by a combination of non-covalent interactions and, even in the case of charged binding pairs, simple ion-ion interactions alone cannot accurately define these recognition processes.
palavras-chave
MIXED-VALENCE; ELECTRON-TRANSFER; PI INTERACTIONS; CHLORIDE-BINDING; MOLECULAR WIRES; CATION-BINDING; DNA-BINDING; RECOGNITION; COMPLEXES; RUTHENIUM
categoria
Chemistry
autores
Zubi, A; Alnafisah, HA; Turega, S; Marques, I; Gomes, JRB; Thomas, JA; Felix, V
nossos autores
Igor Oliveira Marques
Investigador Júnior
José R. B. Gomes
Investigador Principal
Vítor Félix
Professor Associado com Agregaçãoagradecimentos
The computational studies were funded within the scope of the project CICECO-Aveiro Institute of Materials, UIDP/50011/2020, financed by national funds through the Portuguese Foundation for Science and Technology/MCTES. A.Z. is grateful to the Libyan government financial support through a PhD studentship. HAA is grateful for a PhD scholarship provided by the Ministry of Education, Kingdom of Saudi Arabia. We are grateful to the reviewers whose comments and suggestions on this report have substantially improved its quality.