resumo
An efficient methodology for the synthesis of bis[3-(4-chloro-N,N-diethylpyridine-2-carboxamide)] diselenide has been successfully achieved through ring lithiation using 2.2 equivalents of lithium diisopropylamide (LDA) in THF. The hitherto unknown compound has been fully characterized by spectroscopic techniques NMR (1H and 13C), Mass spectrometry and elemental analysis. The crystal structure of bis[3-(4-chloro-N,N-diethylpyridine-2carboxamide)] diselenide has been determined by single crystal X-ray diffraction. The diselenide crystallizes in the monoclinic system (C2/c) with torsional angle of the selenium atoms attached to pyridyl rings (-C1-Se-Se-C1) is -77.5(1). Bis[3-(4-chloro-N,N-diethylpyridine-2-carboxamide)] diselenide was found antibacterial active and results were compared with the most studied pyridylselenium compound (2,2 '-dipyridyl diselenide) and standard drug Ampicillin.
palavras-chave
ANTIOXIDANT ACTIVITY; PYRIDYLSELENIUM COMPOUNDS; ORGANOSELENIUM; DERIVATIVES; LITHIATION; COMPLEXES; CHEMISTRY; OXIDATION; PYRIDYL; SE
categoria
Chemistry, Inorganic & Nuclear
autores
Dhau, JS; Singh, A; Brandao, P; Felix, V
nossos autores
Paula Cristina Ferreira da Silva Brandão
Investigador Auxiliar
Vítor Félix
Professor Associado com Agregaçãoagradecimentos
Crystallographic studies were supported by CICECO-Aveiro Instituteof Materials (UIDB/50011/2020 & UIDP/50011/2020) , financed by National Funds through the FCT/MEC and co-financed by QREN-FEDER through COMPETE under the PT2020 Partnership Agreement. We are also thankful to Dr. Sergey N. Maximoff, R&D, Molekule Inc. for valu-able suggestions for drafting this publication.