Synthesis, characterization, X-ray crystal structure and antibacterial activity of bis[3-(4-chloro-N,N-diethylpyridine-2-carboxamide)] diselenide
authors Dhau, JS; Singh, A; Brandao, P; Felix, V
nationality International
journal INORGANIC CHEMISTRY COMMUNICATIONS
author keywords Pyridyl; Carboxamide; Diselenide; X-ray; Antibacterial
keywords ANTIOXIDANT ACTIVITY; PYRIDYLSELENIUM COMPOUNDS; ORGANOSELENIUM; DERIVATIVES; LITHIATION; COMPLEXES; CHEMISTRY; OXIDATION; PYRIDYL; SE
abstract An efficient methodology for the synthesis of bis[3-(4-chloro-N,N-diethylpyridine-2-carboxamide)] diselenide has been successfully achieved through ring lithiation using 2.2 equivalents of lithium diisopropylamide (LDA) in THF. The hitherto unknown compound has been fully characterized by spectroscopic techniques NMR (1H and 13C), Mass spectrometry and elemental analysis. The crystal structure of bis[3-(4-chloro-N,N-diethylpyridine-2carboxamide)] diselenide has been determined by single crystal X-ray diffraction. The diselenide crystallizes in the monoclinic system (C2/c) with torsional angle of the selenium atoms attached to pyridyl rings (-C1-Se-Se-C1) is -77.5(1). Bis[3-(4-chloro-N,N-diethylpyridine-2-carboxamide)] diselenide was found antibacterial active and results were compared with the most studied pyridylselenium compound (2,2 '-dipyridyl diselenide) and standard drug Ampicillin.
publisher ELSEVIER
issn 1387-7003
isbn 1879-0259
year published 2021
volume 133
digital object identifier (doi) 10.1016/j.inoche.2021.108942
web of science category 6
subject category Chemistry, Inorganic & Nuclear
unique article identifier WOS:000703749900001
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