authors |
Dhau, JS; Singh, A; Brandao, P; Felix, V |
nationality |
International |
journal |
INORGANIC CHEMISTRY COMMUNICATIONS |
author keywords |
Pyridyl; Carboxamide; Diselenide; X-ray; Antibacterial |
keywords |
ANTIOXIDANT ACTIVITY; PYRIDYLSELENIUM COMPOUNDS; ORGANOSELENIUM; DERIVATIVES; LITHIATION; COMPLEXES; CHEMISTRY; OXIDATION; PYRIDYL; SE |
abstract |
An efficient methodology for the synthesis of bis[3-(4-chloro-N,N-diethylpyridine-2-carboxamide)] diselenide has been successfully achieved through ring lithiation using 2.2 equivalents of lithium diisopropylamide (LDA) in THF. The hitherto unknown compound has been fully characterized by spectroscopic techniques NMR (1H and 13C), Mass spectrometry and elemental analysis. The crystal structure of bis[3-(4-chloro-N,N-diethylpyridine-2carboxamide)] diselenide has been determined by single crystal X-ray diffraction. The diselenide crystallizes in the monoclinic system (C2/c) with torsional angle of the selenium atoms attached to pyridyl rings (-C1-Se-Se-C1) is -77.5(1). Bis[3-(4-chloro-N,N-diethylpyridine-2-carboxamide)] diselenide was found antibacterial active and results were compared with the most studied pyridylselenium compound (2,2 '-dipyridyl diselenide) and standard drug Ampicillin. |
publisher |
ELSEVIER |
issn |
1387-7003 |
isbn |
1879-0259 |
year published |
2021 |
volume |
133 |
digital object identifier (doi) |
10.1016/j.inoche.2021.108942 |
web of science category |
6 |
subject category |
Chemistry, Inorganic & Nuclear |
unique article identifier |
WOS:000703749900001
|