Features, Pharmacological Chemistry, Molecular Mechanism and Health Benefits of Lemon
authors Singh, N; Yarla, NS; Siddiqi, NJ; Pereira, MD; Sharma, B
nationality International
journal MEDICINAL CHEMISTRY
author keywords Citrus limon; pharmacochemistry; bioactive; health benefits; nutraceuticals; antioxidants
keywords LIMON ESSENTIAL OIL; CITRUS-LIMON; ANTIOXIDANT ACTIVITY; EXTRACTS; ANTICANCER; MEDICINE; PLANTS; DRUGS; LIVER; BARK
abstract Background: Citrus limon, a Mediterranean-grown citrus species of plants belonging to the Rutaceae family, occupies a place of an impressive range of food and medicinal uses with considerable value in the economy of the fruit of the country. Citrus fruits are economically important with large-scale production of both the fresh fruits and industrially processed products. The extracts and phytochemicals obtained from all parts of C. limon have shown immense therapeutic potential because of their anticancer, anti-tumor and anti-inflammatory nature, and also serve as an important ingredient in the formulation of several ethnic herbal medicines. These properties are mediated by the presence of different phytochemicals, vitamins and nutrients in the citrus fruits. Material and methods: The methods involved in the preparation of the present article included the collection of information from various scientific databases, indexed periodicals, and search engines such as Medline Scopus google scholar PubMed, PubMed central web of science, and science direct. Results: This communication presents an updated account of different pharmacological aspects of C. limon associated with its anti-oxidative, antiulcer, antihelmintic, insecticidal, anticancer, cytotoxic, and estrogenic activities. In addition, C. limon extracts possess hepatoprotective, anti-hyperglycemic, and antimicrobial properties. The present article includes the structure and function of different key chemical constituents from different parts of C. limon. Also, the possible molecular mechanisms of actions of bioactive compounds from C. limon are displayed. Conclusion: The traditional and ethno-medicinal literature revealed that C. limon is very effective in different pathologies. Most of these compounds possessing antioxidant properties would be implicated in offering health benefits by acting as potential nutraceuticals to humans with special reference to disease management of health and disease.
publisher BENTHAM SCIENCE PUBL LTD
issn 1573-4064
isbn 1875-6638
year published 2021
volume 17
issue 3
beginning page 187
ending page 202
digital object identifier (doi) 10.2174/1573406416666200909104050
web of science category 16
subject category Chemistry, Medicinal
unique article identifier WOS:000627229600001
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journal analysis (jcr 2019):
journal impact factor 2.577
5 year journal impact factor 2.764
category normalized journal impact factor percentile 45.082
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