abstract
Various pyridylseleniums and their hydrochloride salts have been synthesized and evaluated for their antibacterial activities. SEM, TEM and enzyme profiling techniques have been used to investigate the mode of action of these compounds as antibiotics. Single crystal X-ray study of bis(3-bromo-2-pyridyl) diselenide (6b) has also been reported. The molecule 6b displays pi center dot center dot center dot pi stacking and pi center dot center dot center dot Br secondary interactions leading to a supramolecular self-assembly. A search on Cambridge Structural Database was undertaken to identify the pi center dot center dot center dot pi stacking interactions in various other bis(2-pyridyl) diselenides. (C) 2014 Elsevier B. V. All rights reserved.
keywords
X-RAY-STRUCTURE; ANTIMICROBIAL PROPERTIES; ORGANOSELENIUM COMPOUNDS; ANTIOXIDANT ACTIVITY; ESCHERICHIA-COLI; DISELENIDE; SELENIDES; COMPLEXES; PYRIDYL
subject category
Chemistry
authors
Dhau, JS; Singh, A; Singh, A; Sooch, BS; Brandao, P; Felix, V
our authors
Groups
1 - inorganic functional nanomaterials and organic-inorganic hybrids
6 - computer simulation and multiscale modeling
acknowledgements
We are thankful to the CSIR, New Delhi, India, for the financial support (Scheme No. 01(2345)/09/EMR-II).