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Equipa
João Mano
Vice-DiretorDescrição
Osteosarcoma is a rare but devastating bone tumour that mainly affects children, adolescents and elderly. This type of tumour is very resistant to therapy, being thus urgent to find new effective treatments. In vitro tumour models can recapitulate many aspects of the natural tumour environment, and could be used to improve the predictive value of the effect of anticancer drug candidates. The aim of MicroBone is the development of biological relevant spherical-based 3D disease models that could be used as an enabling tool for personalized and precision drug discovery, increasing our understanding of the mechanisms behind bone cancer and testing new drug-based therapies.
Coordenador
Coordenação
Universidade de Aveiro (UA)
Resultados
Hydrogel 3D in vitro tumor models for screening cell aggregation mediated drug response
Monteiro, MV; Gaspar, VM; Ferreira, LP; Mano, JFIn-air production of 3D co-culture tumor spheroid hydrogels for expedited drug screening
Antunes, J; Gaspar, VM; Ferreira, L; Monteiro, M; Henrique, R; Jeronimo, C; Mano, JFThree-Dimensional Osteosarcoma Models for Advancing Drug Discovery and Development
Monteiro, CF; Custodio, CA; Mano, JFPhotopolymerizable Platelet Lysate Hydrogels for Customizable 3D Cell Culture Platforms
Santos, SC; Custodio, CA; Mano, JFFinanciadores
Projetos Similares
Actualização e expansão do laboratório de RMN da Universidade de Aveiro
REEQ/934/QUI/2005
