abstract
Pyrazole and pyrazolone moieties have shown important biological activities. For this reason, the synthesis of new derivatives has attracted interest from the scientific community. Herein we report the formation of two unexpected spiro compounds containing pyrazole moieties using a tandem process involving the initial condensation of 3-amino-1-phenyl-2-pyrazolin-5-one with benzaldehyde followed by dimerization.
keywords
CONDENSATION
subject category
Chemistry
authors
Zaiter, J; Achibat, H; Amiri, O; Hafid, A; Khouili, M; Rakib, EM; Neves, CMB; Neves, MGPMS; Silva, AMS; Cavaleiro, JAS; Paz, FAA; Faustino, MAF
our authors
acknowledgements
We would like to thank Fundacao para a Ciencia e a Tecnologia (FCT, Portugal), the European Union, QREN, FEDER, COMPETE, for funding the Organic Chemistry Research Unit (QOPNA) (project PEst-C/QUI/UI0062/2013). CICECO-Aveiro Institute of Materials (Ref. FCT UID/CTM/50011/2013), financed by national funds through the FCT/MEC and when applicable co-financed by FEDER under the PT2020 Partnership Agreement, is also gratefully acknowledged. Authors thank the Portuguese National NMR Network (RNRMN), supported by funds from FCT and also to thank FCT and CICECO for specific funding towards the purchase of the single-crystal diffractometer. C.M.B. Neves also thanks PD/BD/52531/2014 for her PhD Grant. The authors wish to thank the financial support provided by Sultan Moulay Slimane University of Beni-Mellal and the National Center for Scientific and Technical Research, Rabat - Morocco and to the Project Transnational FCT-CNRST-Morocco 2013-2014.