Adenine Derivatives: Promising Candidates for Breast Cancer Treatment
authors Pedro Figueiredo, Marta Costa, Olívia Pontes, Fátima Baltazar and Fernanda Proença
nationality International
journal European Journal Of Organic Chemistry
abstract The cascade reaction of N‐aryl‐5‐{[(dimethylamino)methylene]amino}‐4‐cyanoimidazoles with primary aromatic amines, under reflux in acetic acid, proved to be a general and efficient method for the regioselective synthesis of 6‐arylaminopurines. A selection of these compounds was tested in breast cancer cell models MCF‐7 and Hs578t and five compounds proved to be highly active and non‐toxic to the non‐neoplastic cell line MCF‐10A. Furthermore, the compounds demonstrated apoptosis‐inducing capacity in the cancer cells.
year published 2018
digital object identifier (doi) doi.org/10.1002/ejoc.201800629


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journal impact factor 2.889
5 year journal impact factor 2.53
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