Minimalist Tissue Engineering Approaches Using Low Material-Based Bioengineered Systems
authors Correia, CR; Bjorge, IM; Nadine, S; Mano, JF
nationality International
author keywords low‐ material based strategies; self‐ organization; tissue healing
abstract From an over-engineering era in which biomaterials played a central role, now it is observed to the emergence of developmental tissue engineering (TE) strategies which rely on an integrative cell-material perspective that paves the way for cell self-organization. The current challenge is to engineer the microenvironment without hampering the spontaneous collective arrangement ability of cells, while simultaneously providing biochemical, geometrical, and biophysical cues that positively influence tissue healing. These efforts have resulted in the development of low-material based TE strategies focused on minimizing the amount of biomaterial provided to the living key players of the regenerative process. Through a minimalist-engineering approach, the main idea is to fine-tune the spatial balance occupied by the inanimate region of the regenerative niche toward maximum actuation of the key living components during the healing process.
publisher WILEY
issn 2192-2640
isbn 2192-2659
year published 2021
volume 10
issue 9
digital object identifier (doi) 10.1002/adhm.202002110
web of science category 18
subject category Engineering, Biomedical; Nanoscience & Nanotechnology; Materials Science, Biomaterials
unique article identifier WOS:000627611900001
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journal analysis (jcr 2019):
journal impact factor 7.367
5 year journal impact factor 6.964
category normalized journal impact factor percentile 87.158
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