Sol-Gel Synthesis and Characterization of a Quaternary Bioglass for Bone Regeneration and Tissue Engineering
authors Bento, R; Gaddam, A; Ferreira, JMF
nationality International
author keywords bioactive glasses; alkali-free; sol-gel; bone regeneration; tissue engineering
abstract Sol-gel synthesis using inorganic and/or organic precursors that undergo hydrolysis and condensation at room temperature is a very attractive and less energetic method for preparing bioactive glass (BG) compositions, as an alternative to the melt-quenching process. When properly conducted, sol-gel synthesis might result in amorphous structures, with all of the components intimately mixed at the atomic scale. Moreover, developing new and better performing materials for bone tissue engineering is a growing concern, as the aging of the world's population leads to lower bone density and osteoporosis. This work describes the sol-gel synthesis of a novel quaternary silicate-based BG with the composition 60 SiO2-34 CaO-4 MgO-2 P2O5 (mol%), which was prepared using acidified distilled water as a single solvent. By controlling the kinetics of the hydrolysis and condensation steps, an amorphous glass structure could be obtained. The XRD results of samples calcined within the temperature range of 600-900 degrees C demonstrated that the amorphous nature was maintained until 800 degrees C, followed by partial crystallization at 900 degrees C. The specific surface area-an important factor in osteoconduction-was also evaluated over different temperatures, ranging from 160.6 +/- 0.8 m(2)/g at 600 degrees C to 2.2 +/- 0.1 m(2)/g at 900 degrees C, accompanied by consistent changes in average pore size and pore size distribution. The immersion of the BG particles in simulated body fluid (SBF) led to the formation of an extensive apatite layer on its surface. These overall results indicate that the proposed material is very promising for biomedical applications in bone regeneration and tissue engineering.
publisher MDPI
isbn 1996-1944
year published 2021
volume 14
issue 16
digital object identifier (doi) 10.3390/ma14164515
web of science category 11
subject category Chemistry, Physical; Materials Science, Multidisciplinary; Metallurgy & Metallurgical Engineering; Physics, Applied; Physics, Condensed Matter
unique article identifier WOS:000689561500001
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journal impact factor 3.057
5 year journal impact factor 3.424
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