Short-term exposure to polymethylmethacrylate nanoplastics alters muscle antioxidant response, development and growth in Sparus aurata
authors Balasch, JC; Brandts, I; Barria, C; Martins, MA; Tvarijonaviciute, A; Tort, L; Oliveira, M; Teles, M
nationality International
journal MARINE POLLUTION BULLETIN
author keywords Commercial marine fish; Nanoplastics; Muscle growth; AChE
keywords MYOGENIC REGULATORY FACTORS; IMMUNE ORGANS; SEA; ACETYLCHOLINESTERASE; MICROPLASTICS; EXPRESSION; MYOSTATIN; TISSUE; FISH; GENE
abstract Polymethylmethacrylate (PMMA) plastic fragments have been found abundant in the environment, but the knowledge regarding its effects on the physiology of aquatic animals is still poorly studied. Here the short-term (96 h) effects of waterborne exposure to PMMA nanoplastics (PMMA-NPs) on the muscle of gilthead sea bream (Sparus aurata) fingerlings was evaluated at a concentration range that includes 0.001 up to 10 mg/L. The expression of key transcripts related to cell stress, tissue repair, immune response, antioxidant status and muscle development, together with several biochemical endpoints and metabolic parameters. Results indicate that exposure to PMMA-NPs elicit mildly antioxidant responses, enhanced the acetylcholinesterase (AChE) activity, and inhibited key regulators of muscle development (growth hormone receptors ghr-1/ghr-2 and myostatin, mstn1 transcripts). However, no effects on pro-inflammatory cytokines (interleukin 1 beta, il1 beta and tumor necrosis factor alpha, tnf alpha) expression nor on the levels of energetic substrates (glucose, triglycerides and cholesterol) were found.
publisher PERGAMON-ELSEVIER SCIENCE LTD
issn 0025-326X
isbn 1879-3363
year published 2021
volume 172
digital object identifier (doi) 10.1016/j.marpolbul.2021.112918
web of science category 11
subject category Environmental Sciences; Marine & Freshwater Biology
unique article identifier WOS:000700609200011
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journal analysis (jcr 2019):
journal impact factor 4.049
5 year journal impact factor 4.407
category normalized journal impact factor percentile 85.425
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