In situ generated hemostatic adhesives: From mechanisms of action to recent advances and applications


Conventional surgical closure techniques, such as sutures, clips, or skin closure strips, may not always provide optimal wound closure and may require invasive procedures, which can result in potential post-surgical complications. As result, there is a growing demand for innovative solutions to achieve superior wound closure and improve patient outcomes. To overcome the abovementioned issues, in situ generated hemostatic adhesives/sealants have emerged as a promising alternative, offering a targeted, controllable, and minimally invasive procedure for a wide variety of medical applications. The aim of this review is to provide a comprehensive overview of the mechanisms of action and recent advances of in situ generated hemostatic adhesives, particularly protein-based, thermoresponsive, bioinspired, and photocrosslinkable formulations, as well as the design challenges that must be addressed. Overall, this review aims to enhance a comprehensive understanding of the latest advancements of in situ generated hemostatic adhesives and their mechanisms of action, with the objective of promoting further research in this field.


Luís P.G. Monteiro, João M.M. Rodrigues, João F. Mano

our authors


This work was developed within the scope of the project CICECO-Aveiro Institute of Materials (UIDB/50011/2020, UIDP/50011/2020 & LA/P/0006/2020), financed by national funds through the FCT/MEC (PIDDAC), and within the scope of the project BLUEGLUE (FA_05_2017_031) financed by Fundo Azul (Call – N.° 5/2017) and Direção-Geral de Política do Mar (DGMP) do Ministério Português do Mar. L.P.G.M. and J.M.M.R. gratefully acknowledge FCT for the individual PhD grant (2020.06767.BD — L.P.G.M.) and individual researcher contract under the Scientific Employment Stimulus – Individual Call (CEECIND/01363/2018 — J.M.M.R.), respectively.

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