Cytotoxic activity of lignans from Hibiscus cannabinus

abstract

The antimicrobial and cytotoxic activities of six lignans isolated from the core and bark acetone extracts of Hibiscus cannabinus have been investigated. Two compounds (2 and 3) showed strong cytotoxic activity against HeLa, Hep-2 and A-549 cell lines while compound 5 showed moderate activity on HeLa cells when they were in advanced stage of cellular division. The compounds did not exhibit antimicrobial activity. (c) 2007 Published by Elsevier B.V.

keywords

PHENOLIC CONSTITUENTS; CORE; BARK

subject category

Pharmacology & Pharmacy

authors

Moujir, L; Seca, AML; Silva, AMS; Lopez, MR; Padilla, N; Cavaleiro, JAS; Neto, CP

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