Synthesis of Chiral Bis-MOP-type Diphosphines. Chelating Effect in Nickel-catalyzed Phosphination

resumo

Chiral his-MOP-type diphosphines with alkyl and pyridyl bridges connecting the two binaphthyl units have been synthesized via [NiCl2(dppe)]-assisted phosphination of the corresponding aryl triflates. The effect of the amount of the nickel complex on the reaction yield was investigated. Catalytic and even stoichiometric amounts of the complex proved to be insufficient to promote an efficient phosphination, but the use of an excess of the metal complex provides good yields.

palavras-chave

ASYMMETRIC HYDROGENATION; LIGANDS SYNTHESIS; METAL-COMPLEXES; BINOL; PNP

categoria

Chemistry

autores

Abreu, AR; Peixoto, AF; Almeida, AR; Lourenco, MAO; Neves, ACB; Bayon, JC; Pereira, MM

nossos autores

agradecimentos

The authors are thankful for financial support from Portuguese FCT through project QREN/FEDER/FCT (No. PTDC/QUI-QUI/112913/2009). A. R. Almeida also thanks FCT for Ph.D. grant (No. SFRH/BD/73190/2010).

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