Synthesis of Chiral Bis-MOP-type Diphosphines. Chelating Effect in Nickel-catalyzed Phosphination

abstract

Chiral his-MOP-type diphosphines with alkyl and pyridyl bridges connecting the two binaphthyl units have been synthesized via [NiCl2(dppe)]-assisted phosphination of the corresponding aryl triflates. The effect of the amount of the nickel complex on the reaction yield was investigated. Catalytic and even stoichiometric amounts of the complex proved to be insufficient to promote an efficient phosphination, but the use of an excess of the metal complex provides good yields.

keywords

ASYMMETRIC HYDROGENATION; LIGANDS SYNTHESIS; METAL-COMPLEXES; BINOL; PNP

subject category

Chemistry

authors

Abreu, AR; Peixoto, AF; Almeida, AR; Lourenco, MAO; Neves, ACB; Bayon, JC; Pereira, MM

our authors

acknowledgements

The authors are thankful for financial support from Portuguese FCT through project QREN/FEDER/FCT (No. PTDC/QUI-QUI/112913/2009). A. R. Almeida also thanks FCT for Ph.D. grant (No. SFRH/BD/73190/2010).

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