Microwave assisted extraction of betulin from birch outer bark

resumo

In this communication, we report a new method for the isolation of betulin, a triterpenoid with interesting pharmacological activities, from birch outer bark. Remarkably high purity betulin raw extracts were obtained, ca. 95 wt%, through microwave assisted extraction with limonene. This saves time and energy when compared to the conventional methods.

palavras-chave

NATURAL-PRODUCTS; DRUG DISCOVERY; IONIC LIQUIDS; GREEN SOLVENT; PLANTS; PENDULA; SUBERIN; VACUUM; WASTE

categoria

Chemistry

autores

Ferreira, R; Garcia, H; Sousa, AF; Freire, CSR; Silvestre, AJD; Kunz, W; Rebelo, LPN; Pereira, CS

nossos autores

agradecimentos

R. F. and A. F. S. are grateful to Fundacao para a Ciencia e a Tecnologia (FCT), Portugal, for the fellowships SFRH/BD/48286/2008 and SFRH/BPD/73383/2010, respectively; H. G. is indebted to Fundacao Calouste Gulbenkian, Portugal, for the fellowship 21-95587-B. The work was partially supported by FCT through the Grants PEst-OE/EQB/LA0004/2011, Pest-C/CTM/LA0011/2011, PTDC/QUI-QUI/120982/2010 and REDE/1517/RMN/2005, and by a cooperation grant from FCT and the Deutscher Akademischer Austauschdienst (DAAD).

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