Ecotoxicity of Cholinium-Based Deep Eutectic Solvents


Deep eutectic solvents (DES) are mixtures of hydrogen bond acceptors (HBA) and hydrogen bond donors (HBD) with a melting point much lower than that of either of its components. They have been the focus of interest in past years due to their unique properties, low cost, and wide range of applications. Despite the attention given to DES and their claimed benignity when compared with ionic liquids, their environmental impact is poorly characterized and understood. In this work, the toxicity of some DES prepared with cholinium chloride ([Chol]Cl) as HBA and organic acids, namely acetic, citric, lactic, and glycolic acids, as HBD was measured with the Microtox toxicity test. These DES showed an intermediate toxicity when compared with the respective starting materials and can be considered as "moderately toxic," their toxicity being clearly dominated by the concentration of the acid. They are also shown to be more toxic than their corresponding ionic liquids, namely cholinium glycolate, cholinium acetate, cholinium dihydrogencitrate, and cholinium lactate. Further studies are necessary on the ecotoxicology and biodegradability of DES, namely to evaluate their capability to both classic solvents and ionic liquids. green" character and their alternative capability to both classic solvents and ionic liquids.




Chemistry; Science & Technology - Other Topics; Engineering


de Morais, P; Goncalves, F; Coutinho, JAP; Ventura, SPM

nossos autores


This work was developed in the scope of the project CICECO-Aveiro Institute of Materials (ref. FCT UID/CTM/S0011/2013), financed by national funds through the FCT/MEC and when applicable cofinanced by FEDER under the PT2020 Partnership Agreement. The authors acknowledge FCT for the financial support from the postdoctoral and doctoral scholarships SFRH/BPD/79263/2011 and SFRH/BD/94901/2013 granted to S.P.M.V. and F.A.e.S., respectively. The authors also acknowledge the financial support from FCT under the scope of the project PTDC/AAC-AMB/119172/2010.

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