resumo
Metals have been extensively used for the preservation of wood. Among metallic conservatives, mixtures of chromated copper arsenate (CCA) were thoroughly used. However, the release and consequent mobilization of such compounds by biota, may culminate in the exertion of toxic chemical effects. The present study intended to show the toxicological effects caused by arsenic (7.2 mg/kg body weight), chromium (10.2 mg/kg Cr body weight) and the commercial mixture CCA (7.2 mg/kg As body weight and 10.2 mg/kg Cr body weight) in mice, namely the oxidative stress response (catalase - CAT, glutathione peroxidase - GPx, and glutathione-S-transferases - GSTs), in kidney tissues. The determination of the tested parameters was performed after exposure; organisms were exposed, and then sacrificed at two distinct periods, namely 14 and 96 h after the administration of toxicants. Exposure to chromium and arsenic induced significant modifications in the redox state of the test organisms, evidenced by significant alterations in GSTs and GPx activities. No alterations were found concerning the activity of catalase. These findings showed that the chemical mixture used as household product may exert significant toxicological outcomes in exposed animals, such as rodents, conditioning their redox homeostasis and antioxidant response. (C) 2013 Published by Elsevier B.V.
palavras-chave
GLUTATHIONE-S-TRANSFERASE; CCA-TREATED WOOD; SPRAGUE-DAWLEY RATS; DNA-DAMAGE; HEXAVALENT CHROMIUM; HEAVY-METALS; STRESS; BIOMARKERS; CADMIUM; ACID
categoria
Environmental Sciences & Ecology; Pharmacology & Pharmacy; Toxicology
autores
Matos, RC; Bessa, M; Oliveira, H; Goncalves, F; Pereira, MD; Nunes, B
nossos autores
Helena Oliveira
Bolseiro de pós-Doutoramento
Maria de Lourdes Gomes Pereira
Professor Associado com Agregaçãoagradecimentos
This work was supported by CICECO, and Project