|
authors |
Domingues, RMA; Guerra, AR; Duarte, M; Freire, CSR; Neto, CP; Silva, CMS; Silvestre, AJD |
|
nationality |
International |
|
journal |
MINI-REVIEWS IN ORGANIC CHEMISTRY |
|
author keywords |
Antitumoral activity; betulinic acid; biological activity; birch bark; Eucalyptus; oleanolic acid; olive; triterpenic acids; ursolic acid |
|
keywords |
BREAST-CANCER CELLS; PERFORMANCE LIQUID-CHROMATOGRAPHY; SUPERCRITICAL-FLUID EXTRACTION; EUCALYPTUS-GLOBULUS BARK; MOLECULARLY-IMPRINTED POLYMERS; LIGHT-SCATTERING DETECTION; TETRA-CYCLIC TRITERPENES; POROUS GRAPHITIC CARBON; LIGUSTRUM-LUCIDUM AIT; ANTI-HIV ACTIVITY |
|
abstract |
This review aims to provide an overview of the biogenetic origin of triterpenic acids (with particular emphasis on ursolic, oleanolic and betulinic acids), on the analytical extraction and hyphenated methodologies (mainly GC-MS) used on their identification and quantification, followed by an overview of the major sources of these components, indicating their potential large scale production pathways, with especial emphasis on abundant agroforestry biomass residues. The biological activity of ursolic, oleanolic and betulinic acids is described, focusing on their antitumoral potential as modulators of growth inhibitory signals, evasion of apoptosis and angiogenesis. The future perspectives towards improved therapeutic strategies using these triterpenic acids are also herein discussed. |
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publisher |
BENTHAM SCIENCE PUBL LTD |
|
issn |
1570-193X |
|
year published |
2014 |
|
volume |
11 |
|
issue |
3 |
|
beginning page |
382 |
|
ending page |
399 |
|
web of science category |
Chemistry, Organic |
|
subject category |
Chemistry |
|
unique article identifier |
WOS:000342282600013
|
