On the mechanical properties of PLC-bioactive glass scaffolds fabricated via BioExtrusion


This paper addresses the mechanical characterization of polycaprolactone (PCL)-bioglass (FastOs (R) BG) composites and scaffolds intended for use in tissue engineering. Tissue engineering scaffolds support the self-healing mechanism of the human body and promote the regrowth of damaged tissue. These implants can dissolve after successful tissue regeneration minimising the immune reaction and the need for revision surgery. However, their mechanical properties should match surrounding tissue in order to avoid strain concentration and possible separation at the interface. Therefore, an extensive experimental testing programme of this advanced material using uni-axial compressive testing was conducted. Tests were performed at low strain rates corresponding to quasi-static loading conditions. The initial elastic gradient, plateau stress and densification strain were obtained. Tested specimens varied according to their average density and material composition. In total, four groups of solid and robocast porous PCL samples containing 0, 20, 30, and 35% bioglass, respectively were tested. The addition of bioglass was found to slightly decrease the initial elastic gradient and the plateau stress of the biomaterial scaffolds. (C) 2015 Elsevier B.V. All rights reserved.




Materials Science


Fiedler, T; Videira, AC; Bartolo, P; Strauch, M; Murch, GE; Ferreira, JMF

nossos autores


The authors T. Fiedler and G.E. Murch wish to acknowledge the financial support by the Australian Research Council (ARC) in the framework of the Discovery Project DP130101377.; This work was also supported by the European Regional Development Fund (FEDER) under the PT2020 Partnership Agreement through the COMPETE, by the Portuguese Government through the Portuguese Foundation for Science and Technology (FCT), in the scope of the projects UID/CTM/50011/2013 (Aveiro Institute of Materials, CICECO, www.ciceco.ua.pt) and the fellowship grant Reference PTDC/CTM/99489/2008.

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