Unveiling in Vivo Subcutaneous Thermal Dynamics by Infrared Luminescent Nanothermometers
authors Ximendes, EC; Santos, WQ; Rocha, U; Kagola, UK; Sanz-Rodriguez, F; Fernandez, N; Gouveia-Neto, AD; Bravo, D; Domingo, AM; del Rosal, B; Brites, CDS; Carlos, LD; Jaque, D; Jacinto, C
nationality International
journal NANO LETTERS
author keywords Nanothermometry; rare earth nanoparticles; second biological window; subcutaneous thermal sensing
keywords 2ND BIOLOGICAL WINDOW; CANCER-THERAPY; OPTICAL-PROPERTIES; UP-CONVERSION; FLUORESCENT NANOPARTICLES; CARBON NANOTUBES; ENERGY-TRANSFER; DRUG-DELIVERY; QUANTUM DOTS; TISSUES
abstract The recent development of core/shell engineering of rare earth doped luminescent nanoparticles has ushered a new era in fluorescence thermal biosensing, allowing for the performance of minimally invasive experiments, not only in living cells but also in more challenging small animal models. Here, the potential use of active-core/active-shell Nd3+ - and Yb3+-doped nanoparticles as subcutaneous thermal probes has been evaluated. These temperature nanoprobes operate in the infrared transparency window of biological tissues, enabling deep temperature sensing into animal bodies thanks to the temperature dependence of their emission spectra that leads to a ratiometric temperature readout. The ability of active-core/active-shell Nd3+- and Yb3+-doped nanoparticles for unveiling fundamental tissue properties in in vivo conditions was demonstrated by subcutaneous thermal relaxation monitoring through the injected core/shell nanoparticles. The reported results evidence the potential of infrared luminescence nanothermometry as a diagnosis tool at the small animal level.
publisher AMER CHEMICAL SOC
issn 1530-6984
year published 2016
volume 16
issue 3
beginning page 1695
ending page 1703
digital object identifier (doi) 10.1021/acs.nanolett.5b04611
web of science category Chemistry, Multidisciplinary; Chemistry, Physical; Nanoscience & Nanotechnology; Materials Science, Multidisciplinary; Physics, Applied; Physics, Condensed Matter
subject category Chemistry; Science & Technology - Other Topics; Materials Science; Physics
unique article identifier WOS:000371946300028
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journal analysis (jcr 2019):
journal impact factor 11.238
5 year journal impact factor 12.727
category normalized journal impact factor percentile 89.991
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