Molecular diversity in several pyridyl based Cu(II) complexes: biophysical interaction and redox triggered fluorescence switch
authors Adhlkari, S; Sahana, A; Kumari, B; Ganguly, D; Das, S; Banerjee, PP; Banerjee, G; Chattopadhyay, A; Fondo, M; Matalobos, JS; Brandao, P; Felix, V; Das, D
nationality International
journal NEW JOURNAL OF CHEMISTRY
keywords CALF THYMUS DNA; PI-PI STACKING; CRYSTAL-STRUCTURE; COORDINATION POLYMERS; WILSON-DISEASE; COPPER; SENSOR; CELLS; CU+; ENHANCEMENT
abstract Variation of pyridyl based receptors around a Cu(II) center results in structural diversity allowing redox triggered Cu(II)/Cu(I) fluorescence switch for intracellular Cu(I) imaging. Single crystal X-ray structures of 2-hydroxy-6-methylnicotinic acid (L1), its mono nuclear Cu(II) complex, viz. [Cu(L1)(2)(H2O)(SO4)]center dot 2H(2)O (C1a), polymeric Cu(II) complex (C1b) and a dinuclear Cu(II) complex of 2-(naphthalen-2-ylmethylsulfanyl)nicotinic acid (L4), viz. [Cu-2(L4)(4)(H2O)(2)]center dot 1.12H(2)O (C4) with a Cu-Cu distance of 2.6028(7) angstrom are reported. Moreover, C1a interacts with calf thymus DNA, which is useful for disruption of normal DNA activity with plausible applications in biology (binding constant, K' = 1.56 x 10(4)). Chemical or electrochemical reduction of C1a generates a fluorescent Cu(I) complex. The lowest detection limit of L1 for Cu(I) is 50 mu M. The association constant of L1 for Cu+ is 7.09 x 10(2). Quenching constants of Cu(II) for L1, L2, L3 and L4 are 4 x 10(5), 4.2 x 10(6), 8.9 x 10(5) and 4.4 x 10(6), respectively. The magnetic behavior of C1b indicates a ferromagnetic one-dimensional solid.
publisher ROYAL SOC CHEMISTRY
issn 1144-0546
year published 2016
volume 40
issue 12
beginning page 10378
ending page 10388
digital object identifier (doi) 10.1039/c6nj02381a
web of science category Chemistry, Multidisciplinary
subject category Chemistry
unique article identifier WOS:000390724600062
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journal impact factor 3.288
5 year journal impact factor 3.153
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