Synthesis, mechanical and thermal rheological properties of new gellan gum derivatives

resumo

New derivatives of gellan gum (GG) were prepared by covalent attachment of octadecylamine (C-18-NH2) to polysaccharide backbone via amide linkage by using bis(4-nitrophenyl) carbonate (4-NPBC) as a coupling agent. The effect of the alkyl chain grafted onto hydrophilic backbone of high molecular weight GG was investigated in terms of physicochemical properties and ability of new derivatives to form hydrogels. A series of hydrogels was obtained in solutions with different kind and concentration of ions and their stability and mechanical properties were evaluated. The obtained derivatives resulted soluble at temperature lower than starting GG and physicochemical properties of obtained hydrogels suggested their potential use in biomedical field. (C) 2017 Elsevier B.V. All rights reserved.

palavras-chave

HYALURONIC-ACID; PHYSICOCHEMICAL PROPERTIES; AQUEOUS-SOLUTIONS; GENE DELIVERY; ALGINATE

categoria

Biochemistry & Molecular Biology; Chemistry; Polymer Science

autores

Agnello, S; Gasperini, L; Mano, JF; Pitarresi, G; Palumbo, FS; Reis, RL; Giammona, G

nossos autores

agradecimentos

Authors thank Dr. Ramon Novoa-Carballal for GPC measurements. This work was supported by European Research Council Grant agreement ERC-2012-ADG 20120216-321266 for project ComplexiTE.

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