resumo
This review is focused on the use of membranes for the specific application of bone regeneration. The first section focuses on the relevance of membranes in this context and what are the specifications that they should possess to improve the regeneration of bone. Afterward, several techniques to engineer bone membranes by using bulk-like methods are discussed, where different parameters to induce bone formation are disclosed in a way to have desirable structural and functional properties. Subsequently, the production of nanostructured membranes using a bottom-up approach is discussed by highlighting the main advances in the field of bone regeneration. Primordial importance is given to the promotion of osteoconductive and osteoinductive capability during the membrane design. Whenever possible, the films prepared using different techniques are compared in terms of handability, bone guiding ability, osteoinductivity, adequate mechanical properties, or biodegradability. A last chapter contemplates membranes only composed by cells, disclosing their potential to regenerate bone.
palavras-chave
GUIDED TISSUE REGENERATION; POLYELECTROLYTE MULTILAYER FILMS; MESENCHYMAL STEM-CELLS; BIOACTIVE GLASS NANOPARTICLES; RESORBABLE POLYMERIC MEMBRANES; ENDOTHELIAL GROWTH-FACTOR; OSTEOBLAST-LIKE CELLS; HYDROXYAPATITE/COLLAGEN/PLGA COMPOSITE MEMBRANE; SEGMENTAL DIAPHYSEAL DEFECTS; PLASMA SURFACE MODIFICATION
categoria
Cell Biology; Biotechnology & Applied Microbiology
autores
Caridade, SG; Mano, JF
nossos autores
João Mano
Vice-Diretor
Sofia Caridade
Bolseiro de pós-Doutoramentoagradecimentos
This work was financially supported by the Foundation for Science and Technology (FCT) through the scholarship SFRH/BPD/96797/2013 granted to S.G.C.