resumo
The fabrication of biological substitutes to repair, replace, or enhance tissue- and organ-level functions is a long-sought goal of tissue engineering (TE). However, the clinical translation of TE is hindered by several challenges, including the lack of suitable mechanical, chemical, and biological properties in one biomaterial, and the inability to generate large, vascularized tissues with a complex structure of native tissues. Over the past decade, a new generation of "smart" materials has revolutionized the conventional medical field, transforming TE into a more accurate and sophisticated concept. At the vanguard of scientific development, magnetic nanoparticles (MNPs) have garnered extensive attention owing to their significant potential in various biomedical applications owing to their inherent properties such as biocompatibility and rapid remote response to magnetic fields. Therefore, to develop functional tissue replacements, magnetic force-based TE (Mag-TE) has emerged as an alternative to conventional TE strategies, allowing for the fabrication and real-time monitoring of tissues engineered in vitro. This review addresses the recent studies on the use of MNPs for TE, emphasizing the in vitro, in vivo, and clinical applications. Future perspectives of Mag-TE in the fields of TE and regenerative medicine are also discussed.
palavras-chave
HYALURONIC-ACID HYDROGELS; MESENCHYMAL STEM-CELLS; EXTRACELLULAR-MATRIX; CELLULAR SPHEROIDS; NANOPARTICLES; SCAFFOLDS; SHEETS; FABRICATION; CULTURE; FORCE
categoria
Engineering; Science & Technology - Other Topics; Materials Science
autores
Santos, LF; Silva, AS; Mano, JF
nossos autores
Ana Sofia Matias da Silva
Investigador Auxiliar
João Mano
Vice-DiretorProjectos
CICECO - Aveiro Institute of Materials (UIDB/50011/2020)
CICECO - Aveiro Institute of Materials (UIDP/50011/2020)
Collaboratory for Emerging Technologies, CoLab (EMERGING TECHNOLOGIES)
agradecimentos
The authors acknowledge the CICECO-Aveiro Institute of Materials project, UIDB/50011/2020 and UIDP/50011/2020, financed by national funds through the FCT/MEC, and when appropriate, co-financed by FEDER under the PT2020 Partnership. The authors also acknowledge the financial support from the FCT through a Ph.D. grant (SFRH/BD/141523/2018, L.F.S.) and an individual contract (CEECIND/2020.04344, A.S.S.) and through the FCT project "PROMENADE"(PTDC/BTM-MAT/29830/2017 - POCI-01-0145-FEDER-029830). The support of the European Research Council for the REBORN project (ERC-2019-ADG-883370) is acknowledged.