Design, structural characterization and cytotoxic properties of copper(I) and copper(II) complexes formed by vitamin B-3 type
authors Anacleto, B; Gomes, P; Correia-Branco, A; Silva, C; Martel, F; Brandao, P
nationality International
journal POLYHEDRON
author keywords Copper(I) and copper(II) complexes; Vitamin B-3; Hydroxyl-vitamin B-3; Phenanthroline; Caco-2 cells
keywords DINUCLEAR METAL-COMPLEXES; CRYSTAL-STRUCTURE; DNA-BINDING; COORDINATION POLYMER; HYDROTHERMAL SYNTHESIS; ANTITUMOR-ACTIVITY; ANTICANCER DRUGS; CU(II) COMPLEXES; LIGAND; CLEAVAGE
abstract Four new examples of copper complexes [Cu(L1)(2)(H2O)(4)] (1), [Cu(HL1)(2)(H2O)(2)](NO3)(2) (2), [Cu(HL1)CI](infinity) (3), [Cu(HL2)(phen)(H2O)](NO3)center dot 3(H2O) (4) with HL1 = vitamin B-3, H(2)L2 = 2-hydroxy-vitamin B-3, phen = 1,10-phenanthroline, were synthesized and their structures solved by single crystal X-ray diffraction. For all complexes, vitamin B-3 acts as monodentate ligand through the N atom from pyridyl group or the oxygen atom from the carboxylate group. The copper centers exhibit different geometries, namely octahedral (1), square planar (2), tetrahedral (3) and square pyramidal (4). Intermolecular pi center dot center dot center dot pi interactions as well as an H-bonding network were observed for all complexes. The antitumor capacity of the complexes was tested in vitro against a human cancer cell line, the colorectal adenocarcinoma (Caco-2) cell line, by determining their effect on cell viability, using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-tetrazolium bromide as reagent. Noteworthy, complex of copper(II) with hydroxyl-vitamin B3 and phenanthroline (4) showed a considerable lower IC50 value (30 (24-38) mu M), when compared with vitamin B-3, phenanthroline and cisplatin against the same cell line. Crown Copyright (C) 2017 Published by Elsevier Ltd. All rights reserved.
publisher PERGAMON-ELSEVIER SCIENCE LTD
issn 0277-5387
year published 2017
volume 138
beginning page 277
ending page 286
digital object identifier (doi) 10.1016/j.poly.2017.09.030
web of science category Chemistry, Inorganic & Nuclear; Crystallography
subject category Chemistry; Crystallography
unique article identifier WOS:000417662300033
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journal analysis (jcr 2019):
journal impact factor 2.343
5 year journal impact factor 1.894
category normalized journal impact factor percentile 60.363
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