Designer solvent ability of alcohols in aqueous biphasic systems composed of deep eutectic solvents and potassium phosphate


Deep eutectic solvents (DES) have been proposed as phase forming components of aqueous biphasic systems (ABS). However, the DES hydrogen bonding complexes are not stable in the high concentrations of water present in this type of systems. Therefore, as previously shown, DES-based ABS should be treated as quaternary systems. This confers DES-based ABS with an extra degree of freedom for the design of separation processes since while one of the DES components acts as a phase forming component, the other could induce the modification of the ABS phase properties and, consequently, the control of the partition of various biomolecules. In this context, the designer solvent effect of the hydrogen bond donor (HBD), using four different alcohols - ethanol, n-propanol 1,2-propanediol and ethylene glycol - mixed at three different molar fractions (2:1; 1:1 and 1:2) with cholinium chloride (the hydrogen bond acceptor, HBA) in quaternary systems composed of K2HPO4 and water, was evaluated in this work. The results show that the presence of the HBD has an impact upon the liquid-liquid equilibrium, and these changes are dependent on the alcohol nature. The NRTL model was correlated to the tie line experimental data with a low mean deviation. Moreover, several biomolecules (phenolic compounds, alkaloids, and amino acids) were use as molecular probes to evaluate the ability of alcohols to tune the partition in the studied systems. The alcohol presence changes the properties of the ABS's phases and it is here shown that the HBD of the DES can indeed be used to modulate the partition behavior of target molecules.






Farias, FO; Passos, H; Sanglard, MG; Igarashi-Mafra, L; Coutinho, JAP; Mafra, MR

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This work was developed within the scope of the project CICECO-Aveiro Institute of Materials, POCI-01-0145-FEDER-007679 (FCT Ref. UID/CTM/50011/2013), financed by national funds through the FCT/MEC and when appropriate co-financed by FEDER under the PT2020 Partnership Agreement. F.O. Farias is grateful for the scholarship provided by CAPES (Coordenacao de Aperfeicoameno de Pessoal de Nivel Superior, Brazil). M. Mafra is grateful for Brazilian National Council for Scientific and Technological Development (CNPq - Grant 310905/2015-0). The authors also acknowledge Fundacao da Ciencia e da Tecnologia for the financial support through the project SAICTPAC/0040/2015.

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