resumo
The growing resistance of pathogens to conventional antibiotics has become a public health problem requiring novel effective solutions. In this context, metal-organic frameworks (MOFs) are attracting attention because they can act as reservoirs releasing metal ions with antibacterial properties. This action is reminiscent of that proposed for metal- and metal oxide-nanoparticles but different from the action of antibiotics. These features make MOFs promising candidates for pharmaceutical and biomedical applications. Here, IRMOF-3 was modified with 2,5-dimethoxytetrahydrofuran, N,N '-disuccinimidyl carbonate, acryloyl chloride, and phthalaldehyde to produce, respectively, IRMOF-3-FU, IRMOF-3-SU, IRMOF-3-AC, IRMOF-3-DL in 38 to 90 % yields. Remarkably, the biological activity of these compounds evaluated against various bacterial and fungal strains is higher than the activity of commercial antibiotics.
palavras-chave
METAL-ORGANIC FRAMEWORKS; ANTIMICROBIAL ACTIVITY; DERIVATIVES; CHITOSAN; MOFS
categoria
Chemistry
autores
Abdelhameed, RM; Darwesh, OM; Rocha, J; Silva, AMS
nossos autores
João Rocha
Prof. Catedrático
Reda Mohamed Abdelhameed Ahmed
Bolseiro de pós-Doutoramentoagradecimentos
Thanks are due to University of Aveiro and FCT/MEC for the financial support to the QOPNA research project (FCT UID/QUI/00062/2013) and to the CICECO-Aveiro Institute of Materials (POCI-01-0145-FEDER-007679; FCT UID/CTM/50011/2013), financed by national funds and when appropriate co-financed by FEDER under the PT2020 Partnership Agreement, and to the Portuguese NMR Network. We further wish to thank CICECO and STDF (project number 25313) for the grant given to R. M. Abdelhameed and for funding the purchase of the single-crystal X-ray diffractometer.