resumo
The emergence of multidrug-resistant bacteria and fungi requires the development of antibiotics and antifungal agents. This review identified natural products isolated from Asian angiosperms with antibacterial and/or antifungal activities and analyzed their distribution, molecular weights, solubility, and modes of action. All data in this review were compiled from Google Scholar, PubMed, Science Direct, Web of Science, ChemSpider, PubChem, and a library search from 1979 to 2022. One hundred and forty-one antibacterial and/or antifungal alkaloids were identified during this period, mainly from basal angiosperms. The most active alkaloids are mainly planar, amphiphilic, with a molecular mass between 200 and 400 g/mol, and a polar surface area of about 50 A(2), and target DNA and/or topoisomerase as well as the cytoplasmic membrane. 8-Acetylnorchelerythrine, cryptolepine, 8-hydroxydihydrochelerythrine, 6-methoxydihydrosanguinarine, 2 '-nortiliacorinine, pendulamine A and B, rhetsisine, sampangine, tiliacorine, tryptanthrin, tylophorinine, vallesamine, and viroallosecurinine yielded MIC <= 1 mu g/mL and are candidates for the development of lead molecules.
palavras-chave
TOPOISOMERASE-II INHIBITION; ANTIMICROBIAL ACTIVITY; INDOLE ALKALOIDS; CHEMICAL-CONSTITUENTS; CARBAZOLE ALKALOIDS; MURRAYA-KOENIGII; BISBENZYLISOQUINOLINE ALKALOIDS; ANTIMYCOBACTERIAL ACTIVITY; CYTOTOXIC ACTIVITIES; ALSTONIA-SCHOLARIS
categoria
Infectious Diseases; Pharmacology & Pharmacy
autores
Sulaiman, M; Jannat, K; Nissapatorn, V; Rahmatullah, M; Paul, AK; Pereira, MD; Rajagopal, M; Suleiman, M; Butler, MS; Bin Break, MK; Weber, JF; Wilairatana, P; Wiart, C
nossos autores
Maria de Lourdes Gomes Pereira
Professor Associado com AgregaçãoProjectos
CICECO - Aveiro Institute of Materials (UIDB/50011/2020)
CICECO - Aveiro Institute of Materials (UIDP/50011/2020)
Associated Laboratory CICECO-Aveiro Institute of Materials (LA/P/0006/2020)
agradecimentos
This project was funded by a grant from the Malaysian Ministry of Education (FRGS/1/2018/WAB07/UNIM/02/1, Malaysian Ministry of Higher Education, Malaysia) and Project CICECOAveiro Institute of Materials, UIDB/50011/2020, UIDP/50011/2020 & LA/P/0006/2020, financed by national funds through the FCT/MEC (PIDDAC).