resumo
Pure and five silver-doped (0-5Ag) beta-tricalcium phosphate [beta-TCP, beta-Ca-3(PO4)(2)]/chitosan composite coatings were deposited on Titanium (Ti) substrates and their properties that are relevant for applications in hard tissue replacements were assessed. Silver, beta-TCP and chitosan were combined to profit from their salient and complementary antibacterial and biocompatible features. The beta-Ca-3(PO4)(2) powders were synthesized by co-precipitation. The characterization results confirmed the Ag+ occupancy at the crystal lattice of beta-Ca-3(PO4)(2). The Ag-doped beta-Ca-3(PO4)(2)/chitosan composite coatings deposited by electrophoresis showed good antibacterial activity and exhibited negative cytotoxic effects towards the human osteosarcoma cell line MG-63. The morphology of the coatings was observed by SEM and their efficiency against corrosion of metallic substrates was determined through potentiodynamic polarization tests. (C) 2016 Elsevier B.V. All rights reserved.
palavras-chave
BETA-TRICALCIUM PHOSPHATE; SILVER NANOPARTICLES; ANTIBACTERIAL ACTIVITY; ANTIMICROBIAL ACTIVITY; STAPHYLOCOCCUS-AUREUS; CALCIUM PHOSPHATES; DEFICIENT APATITE; ESCHERICHIA-COLI; HYDROXYAPATITE; IONS
categoria
Materials Science
autores
Singh, RK; Awasthi, S; Dhayalan, A; Ferreira, JMF; Kannan, S
nossos autores
José Maria da Fonte Ferreira
Professor(a) Jubilado(a)agradecimentos
The financial assistance received from Department of Science and Technology, DST [Reference:SB/FT/CS-101/2012(SR)], India is acknowledged. The facilities availed from Central Instrumentation Facility (CIF) of Pondicherry University are also acknowledged. This work was also supported by the European Regional Development Fund (FEDER) under the PT2020 Partnership Agreement through the COMPETE, by the Portuguese Government through the Portuguese Foundation for Science and Technology (FCT), in the scope of the projects UID/CTM/50011/2013 (Aveiro Institute of Materials, CICECO,www.ciceco.ua.pt) and the fellowship grant Reference PTDC/CTM/99489/2008.