resumo
Developing multifunctional therapeutic and diagnostic (theranostic) nanoplatforms is critical for addressing challenging issues associated with cancers. Here, self-assembled supernanoparticles consisting of superparamagnetic Fe3O4 nanoparticles and photo luminescent PbS/CdS quantum dots whose emission lies within the second biological window (II-BW) are developed. The proposed self assembled Fe3O4 and PbS/CdS (II-BW) supernanoparticles [SASNs (II-BW)] exhibit outstanding photoluminescence detectable through a tissue as thick as 14 mm, by overcoming severe light extinction and concomitant autofluorescence in II-BW, and significantly enhanced T-2 relaxivity (282 mM(-1) s(-1), ca. 4 times higher than free Fe3O4 nanoparticles) due to largely enhanced magnetic field inhomogeneity. On the other hand, SASNs (II-BW) possess the dual capacity to act as both magnetothermal and photothermal agents, overcoming the main drawbacks of each type of heating separately. When SASNs (II-BW) are exposed to the dual-mode (magnetothermal and photothermal) heating, the thermal energy transfer efficiency is amplified 7-fold compared with magnetic heating alone. These results, in hand with the excellent photo- and colloidal stability, and negligible cytotoxicity, demonstrate the potential use of SASNs (II-BW) for deep-tissue bimodal (magnetic resonance and photoluminescence) in vivo imaging, while simultaneously providing the possibility of SASNs (II-BW)-mediated amplified dual-mode heating treatment for cancer therapy.
palavras-chave
IRON-OXIDE NANOPARTICLES; PBS QUANTUM DOTS; MAGNETIC-RESONANCE; PHOTOTHERMAL THERAPY; HIGH-PERFORMANCE; CANCER-THERAPY; SIZE; NANOCRYSTALS; HYPERTHERMIA; EFFICIENCY
categoria
Chemistry; Science & Technology - Other Topics; Materials Science
autores
Yang, F; Skripka, A; Tabatabaei, MS; Hong, SH; Ren, FQ; Benayas, A; Oh, JK; Martel, S; Liu, XY; Vetrone, F; Ma, DL
nossos autores
Antonio Hernández Benayas
InvestigadorGrupos
Projectos
Solucao de Engenharia Microestrutural para Aumentar o Transporte Ionico Interfacial (MERIT)
agradecimentos
D.M. and F.V. are grateful to the Natural Sciences and Engineering Research Council of Canada (NSERC: RGPIN-2015-06756) and the Fonds de Recherche du Quebec - Nature et Technologies (FRQNT: 2014-PR-174462) for funding. F.Y., F.R., and A.S. greatly appreciate the financial support from the Merit Scholarship Program for Foreign Students from the Ministere de l'Education, du Loisir et du Sport du Quebec (No. 193353, No. 255072, and No. 257149). We would like to thank J.X. from Soochow University for the help with in vivo experiments. We acknowledge Z.Y. from Peking University for the magnetic characterization.