Coating of Magnetite Nanoparticles with Fucoidan to Enhance Magnetic Hyperthermia Efficiency

resumo

Magnetic nanoparticles (NP), such as magnetite, have been the subject of research for application in the biomedical field, especially in Magnetic Hyperthermia Therapy (MHT), a promising technique for cancer therapy. NP are often coated with different compounds such as natural or synthetic polymers to protect them from oxidation and enhance their colloidal electrostatic stability while maintaining their thermal efficiency. In this work, the synthesis and characterization of magnetite nanoparticles coated with fucoidan, a biopolymer with recognized biocompatibility and antitumoral activity, is reported. The potential application of NP in MHT was evaluated through the assessment of Specific Loss Power (SLP) under an electromagnetic field amplitude of 14.7 kA m(-1) and at 276 kHz. For fucoidan-coated NP, it was obtained SLP values of 100 and 156 W/g, corresponding to an Intrinsic Loss Power (ILP) of 1.7 and 2.6 nHm(2)kg(-1), respectively. These values are, in general, higher than the ones reported in the literature for non-coated magnetite NP or coated with other polymers. Furthermore, in vitro assays showed that fucoidan and fucoidan-coated NP are biocompatible. The particle size (between ca. 6 to 12 nm), heating efficiency, and biocompatibility of fucoidan-coated magnetite NP meet the required criteria for MHT application.

palavras-chave

IRON-OXIDE NANOPARTICLES; FE3O4 NANOPARTICLES; POLYETHYLENE-GLYCOL; BIOLOGICAL-ACTIVITY; CANCER; POLYSACCHARIDES; ACID; FUNCTIONALIZATION; CHEMOTHERAPY; PROGRESS

categoria

Chemistry, Multidisciplinary; Nanoscience & Nanotechnology; Materials Science, Multidisciplinary; Physics, Applied

autores

Goncalves, J; Nunes, C; Ferreira, L; Cruz, MM; Oliveira, H; Bastos, V; Mayoral, A; Zhang, Q; Ferreira, P

Grupos

G2 - Materiais Fotónicos, Eletrónicos e Magnéticos
G4 - Materiais Renováveis e Economia Circular

Projectos

CICECO - Aveiro Institute of Materials (UIDB/50011/2020)

CICECO - Aveiro Institute of Materials (UIDP/50011/2020)

Nanopartículas Magnéticas estruturadas (OrMagNa)

Projeto de Investigação Exploratória: Paula Ferreira (IF_Paula Ferreira)

HOTsPOT - Novel upconversion nanoparticles for multimodal therapy of melanoma: pHOtothermal Therapy, PhOtodynamic therapy and chemoTherapy (HOTsPOT)

Nano-argilas para remoção/captura de fosfatos (P) e sua reutilização como fertilizante (NATURAL)

agradecimentos

This work was developed within the scope of the project CICECO-Aveiro Institute of Materials, UIDB/50011/2020 & UIDP/50011/2020, financed by national funds through the Portuguese Foundation for Science and Technology/MCTES. The work was also funded through FCT projects PTDC/NAN-MAT/28785/2017 (OrMagNa), UID/MULTI/04046/2019 (BioISI) and UIDP/50017/2020 & UIDB/50017/2020 (CESAM). This work was also funded by national funds (OE), through FCT-Fundacao para a Ciencia e a Tecnologia, I.P., in the scope of the framework contract foreseen in the numbers 4, 5 and 6 of the article 23, of the Decree-Law 57/2016, of August 29, changed by Law 57/2017, of July 19. The Portuguese Foundation for Science and Technology (FCT) is also acknowledged for the research contract under Stimulus of Scientific Employment of P. Ferreira (IF/00300/2015) and H. Oliveira (CEECIND/04050/2017), the Post-Doctoral grant of C. Nunes (SFRH/BPD/100627/2014), and the research contract of V. Bastos (CDL-CTTRI-161-ARH/2018) funded by the FCT project (POCI-01-0145-FEDER-031794). AM acknowledges the Spanish Ministry of Science (RYC2018-024561-I) and to the Natural National Science Foundation of China through the grants NSFC-21850410448 & NSFC-21835002. The authors acknowledge to The Centre for High-resolution Electron Microscopy (ChEM), supported by SPST of ShanghaiTech University under contract No. EM02161943. This project has received funding from the European Union's Horizon 2020 research and innovation programme under grant agreement No 823717-ESTEEM3.