Biomedical applications of laminarin

resumo

The ocean is par excellence a fertile territory of biodiversity on our planet. Marine-derived polysaccharides have been applied as functional materials in biomedicine due to their attractive bioactive properties, safety, high availability and low-cost production. Laminarin (or laminaran), a low molecular weight beta-glucan storage polysaccharide present in brown algae, can be (bio-) chemically modified to enhance its biological activity and employed in cancer therapies, drug/gene delivery, tissue engineering, antioxidant and anti-inflammatory functions. This review provides a brief overview on laminarin characteristics, modification strategies and highlights its pivotal biomedical applications.

palavras-chave

IN-VITRO; ANTICANCER ACTIVITY; BETA-GLUCAN; MARINE POLYSACCHARIDES; ANTIOXIDANT ACTIVITIES; CELL-ADHESION; BROWN; EXTRACTION; ANTITUMOR; ALGAE

categoria

Chemistry; Polymer Science

autores

Zargarzadeh, M; Amaral, AJR; Custodio, CA; Mano, JF

nossos autores

agradecimentos

The authors would like to acknowledge the European Research Council Grant Agreement ERC-2014-ADG-669858 for project ATLAS.

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